CELA2A

Protein identityUniProt · HPA

UniProt accession

P08217

Gene

CELA2A

Ensembl

ENSG00000142615

Chromosome

1

Canonical length

269 aa

Protein class

Disease related genes, Enzymes, Human disease related genes, Potential drug targets, Predicted secreted proteins

Secretome location

Secreted to digestive system

OverviewNCBI Gene

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins elastase 1, 2, 2A, 2B, 3A, and 3B. Like most of the human elastases, elastase 2A is secreted from the pancreas as a zymogen. In other species, elastase 2A has been shown to preferentially cleave proteins after leucine, methionine, and phenylalanine residues. [provided by RefSeq, May 2009]

Canonical amino-acid sequenceUniProt

269 residues, UniProt reviewed canonical sequence.

>P08217|CELA2A
     1  MIRTLLLSTL VAGALSCGDP TYPPYVTRVV GGEEARPNSW PWQVSLQYSS NGKWYHTCGG
    61  SLIANSWVLT AAHCISSSRT YRVGLGRHNL YVAESGSLAV SVSKIVVHKD WNSNQISKGN
   121  DIALLKLANP VSLTDKIQLA CLPPAGTILP NNYPCYVTGW GRLQTNGAVP DVLQQGRLLV
   181  VDYATCSSSA WWGSSVKTSM ICAGGDGVIS SCNGDSGGPL NCQASDGRWQ VHGIVSFGSR
   241  LGCNYYHKPS VFTRVSNYID WINSVIANN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CELA2A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Secreted

Secreted

Yes

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.26

Highest tissue expression

153,460 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CELA2A.

Disease | AllUniProt

Conditions CELA2A is implicated in, by any mechanism.

• Abdominal obesity-metabolic syndrome 4 (AOMS4) MIM:618620

Disease | GeneticClinVar

5 pathogenic / likely-pathogenic of 56 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Abdominal obesity-metabolic syndrome 4
• Coronary artery disorder
• Hypertriglyceridemia
• Diabetes
• Hypertensive disorder

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.83

gnomAD pLI

0

gnomAD missense Z

0.04

DepMap mean gene effect

-0.05

DepMap dependency class

selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• insulin catabolic process
• proteolysis
• regulation of insulin secretion
• regulation of platelet aggregation
• response to insulin

Molecular functions

• endopeptidase activity
• serine hydrolase activity
• serine-type endopeptidase activity

Cellular components

• cytosol
• extracellular region
• extracellular space
• keratohyalin granule

Protein domainsUniProt · Pfam · InterPro

• Serine proteases, trypsin domain
• Peptidase S1A, chymotrypsin family
• Peptidase S1, PA clan
• Serine proteases, trypsin family, histidine active site
• Serine proteases, trypsin family, serine active site
• Peptidase S1 family, Elastase subfamily
• Trypsin

KeywordsUniProt

• Diabetes mellitus
• Disulfide bond
• Hydrolase
• Obesity
• Protease
• Secreted
• Serine protease
• Signal
• Zymogen

InteractionsUniProt · HPA

Protein binding partners of CELA2A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CPA1
• SERPINA1