CEACAM8
Cell adhesion molecule CEACAM8
Also known as: CD66b, CEAM8_HUMAN, CGM6
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- P31997
- Gene
- CEACAM8
- Ensembl
- ENSG00000124469
- Chromosome
- 19
- Canonical length
- 349 aa
- Protein class
- CD markers, Plasma proteins, Predicted intracellular proteins
- Secretome location
- Intracellular and membrane
OverviewNCBI Gene
Enables protein heterodimerization activity. Involved in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules. Located in cell surface and extracellular space. Biomarker of severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
349 residues, UniProt reviewed canonical sequence.
>P31997|CEACAM8
1 MGPISAPSCR WRIPWQGLLL TASLFTFWNP PTTAQLTIEA VPSNAAEGKE VLLLVHNLPQ
61 DPRGYNWYKG ETVDANRRII GYVISNQQIT PGPAYSNRET IYPNASLLMR NVTRNDTGSY
121 TLQVIKLNLM SEEVTGQFSV HPETPKPSIS SNNSNPVEDK DAVAFTCEPE TQNTTYLWWV
181 NGQSLPVSPR LQLSNGNRTL TLLSVTRNDV GPYECEIQNP ASANFSDPVT LNVLYGPDAP
241 TISPSDTYYH AGVNLNLSCH AASNPPSQYS WSVNGTFQQY TQKLFIPNIT TKNSGSYACH
301 TTNSATGRNR TTVRMITVSD ALVQGSSPGL SARATVSIMI GVLARVALILocalizationUniProt · AlphaFold · HPA
Whether an antibody against CEACAM8 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.37
- Highest tissue expression
- 205 nTPM
Expression across tissuesHPA
Tissue
- bone marrow: 205 nTPM
- spleen: 5.6 nTPM
- lung: 1.7 nTPM
- thymus: 1.6 nTPM
- colon: 0.4 nTPM
- placenta: 0.4 nTPM
Single-cell type
- neutrophil progenitors: 1,217 nCPM
- neutrophils: 94 nCPM
- adipocytes: 35 nCPM
- erythrocytes: 4.4 nCPM
- cardiomyocytes: 4 nCPM
- hematopoietic stem cells: 3.9 nCPM
Immune cell
- total PBMC: 2.7 nTPM
- neutrophil: 1.6 nTPM
- non-classical monocyte: 1.1 nTPM
- basophil: 0.2 nTPM
- eosinophil: 0.2 nTPM
- NK-cell: 0.2 nTPM
Brain region
- cerebral cortex: 5.2 nTPM
- cerebellum: 4.8 nTPM
- amygdala: 4.7 nTPM
- hippocampal formation: 4.1 nTPM
- hypothalamus: 4 nTPM
- basal ganglia: 3.9 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.21
- gnomAD pLI
- 0
- gnomAD missense Z
- -0.57
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CEACAM8 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CEACAM8 as an antibody target. Whether an autoantibody or antibody against CEACAM8 could matter depends on whether native CEACAM8 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CEACAM8 is annotated at the cell surface, where native CEACAM8 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label CEACAM8 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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