Seroatlas · Human Serome Atlas

CEACAM6

Cell adhesion molecule CEACAM6

Also known as: CD66c, CEAM6_HUMAN, NCA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P40199
Gene
CEACAM6
Ensembl
ENSG00000086548
Chromosome
19
Canonical length
344 aa
Protein class
Cancer-related genes, CD markers, Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure
Homodimer

OverviewNCBI Gene

This gene encodes a protein that belongs to the carcinoembryonic antigen (CEA) family whose members are glycosyl phosphatidyl inositol (GPI) anchored cell surface glycoproteins. Members of this family play a role in cell adhesion and are widely used as tumor markers in serum immunoassay determinations of carcinoma. This gene affects the sensitivity of tumor cells to adenovirus infection. The protein encoded by this gene acts as a receptor for adherent-invasive E. coli adhesion to the surface of ileal epithelial cells in patients with Crohn's disease. This gene is clustered with genes and pseudogenes of the cell adhesion molecules subgroup of the CEA family on chromosome 19. [provided by RefSeq, Apr 2014]

Canonical amino-acid sequenceUniProt

344 residues, UniProt reviewed canonical sequence.

>P40199|CEACAM6
     1  MGPPSAPPCR LHVPWKEVLL TASLLTFWNP PTTAKLTIES TPFNVAEGKE VLLLAHNLPQ
    61  NRIGYSWYKG ERVDGNSLIV GYVIGTQQAT PGPAYSGRET IYPNASLLIQ NVTQNDTGFY
   121  TLQVIKSDLV NEEATGQFHV YPELPKPSIS SNNSNPVEDK DAVAFTCEPE VQNTTYLWWV
   181  NGQSLPVSPR LQLSNGNMTL TLLSVKRNDA GSYECEIQNP ASANRSDPVT LNVLYGPDVP
   241  TISPSKANYR PGENLNLSCH AASNPPAQYS WFINGTFQQS TQELFIPNIT VNNSGSYMCQ
   301  AHNSATGLNR TTVTMITVSG SAPVLSAVAT VGITIGVLAR VALI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEACAM6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.36
Highest tissue expression
270 nTPM

Expression across tissuesHPA

Tissue

  • lung: 270 nTPM
  • rectum: 207 nTPM
  • esophagus: 195 nTPM
  • colon: 183 nTPM
  • salivary gland: 178 nTPM
  • bone marrow: 171 nTPM

Single-cell type

  • esophageal apical cells: 2,066 nCPM
  • alveolar cells type 1: 1,945 nCPM
  • transitional alveolar cells: 847 nCPM
  • colonocytes: 473 nCPM
  • respiratory deuterosomal cells: 465 nCPM
  • respiratory secretory cells: 449 nCPM

Immune cell

  • total PBMC: 3.1 nTPM
  • neutrophil: 1.1 nTPM
  • naive B-cell: 0.6 nTPM
  • non-classical monocyte: 0.6 nTPM
  • intermediate monocyte: 0.5 nTPM
  • classical monocyte: 0.1 nTPM

Brain region

  • basal ganglia: 4.6 nTPM
  • cerebellum: 3.3 nTPM
  • cerebral cortex: 3.1 nTPM
  • white matter: 2.9 nTPM
  • medulla oblongata: 2.7 nTPM
  • amygdala: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
-0.19
DepMap mean gene effect
-0.22
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEACAM6 as an antibody target. Whether an autoantibody or antibody against CEACAM6 could matter depends on whether native CEACAM6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEACAM6 is annotated at the cell surface, where native CEACAM6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CEACAM6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CEACAM6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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