Seroatlas · Human Serome Atlas

CEACAM4

Cell adhesion molecule CEACAM4

Also known as: CEAM4_HUMAN, CGM7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O75871
Gene: CEACAM4
Ensembl: ENSG00000105352
Chromosome: 19
Canonical length: 244 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to enable protein tyrosine kinase binding activity. Involved in phagocytosis. Predicted to be located in membrane. Predicted to be active in cell surface and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

244 residues, UniProt reviewed canonical sequence.

>O75871|CEACAM4
     1  MGPPSAAPRG GHRPWQGLLI TASLLTFWHP PTTVQFTIEA LPSSAAEGKD VLLLACNISE
    61  TIQAYYWHKG KTAEGSPLIA GYITDIQANI PGAAYSGRET VYPNGSLLFQ NITLEDAGSY
   121  TLRTINASYD SDQATGQLHV HQNNVPGLPV GAVAGIVTGV LVGVALVAAL VCFLLLSRTG
   181  RASIQRDLRE QPPPASTPGH GPSHRSTFSA PLPSPRTATP IYEELLYSDA NIYCQIDHKA
   241  DVVS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEACAM4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.48
Highest tissue expression: 33 nTPM

Expression across tissuesHPA

Tissue

spleen: 33 nTPM
bone marrow: 7.1 nTPM
lung: 5.7 nTPM
adipose tissue: 2 nTPM
pancreas: 2 nTPM
appendix: 1.7 nTPM

Single-cell type

neutrophils: 18 nCPM
hematopoietic stem cells: 11 nCPM
monocytes: 5.8 nCPM
monocyte progenitors: 5.7 nCPM
kupffer cells: 5.1 nCPM
neutrophil progenitors: 4.5 nCPM

Immune cell

neutrophil: 241 nTPM
classical monocyte: 61 nTPM
myeloid DC: 48 nTPM
intermediate monocyte: 46 nTPM
total PBMC: 25 nTPM
T-reg: 24 nTPM

Brain region

choroid plexus: 0.6 nTPM
medulla oblongata: 0.6 nTPM
amygdala: 0.4 nTPM
basal ganglia: 0.3 nTPM
cerebral cortex: 0.3 nTPM
hypothalamus: 0.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.42
gnomAD pLI: 0
gnomAD missense Z: -0.75
DepMap mean gene effect: -0.02
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

protein tyrosine kinase binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEACAM4 as an antibody target. Whether an autoantibody or antibody against CEACAM4 could matter depends on whether native CEACAM4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEACAM4 is annotated at the cell surface, where native CEACAM4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CEACAM4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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