Seroatlas · Human Serome Atlas

CEACAM21

Cell adhesion molecule CEACAM21

Also known as: CEA21_HUMAN, FLJ13540, R29124_1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q3KPI0
Gene: CEACAM21
Ensembl: ENSG00000007129
Chromosome: 19
Canonical length: 293 aa
Protein class: Predicted membrane proteins

OverviewNCBI Gene

Predicted to be involved in T cell activation and immune response. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

293 residues, UniProt reviewed canonical sequence.

>Q3KPI0|CEACAM21
     1  MGPPSACPHR ECIPWQGLLL TASLLTFWNA PTTAWLFIAS APFEVAEGEN VHLSVVYLPE
    61  NLYSYGWYKG KTVEPNQLIA AYVIDTHVRT PGPAYSGRET ISPSGDLHFQ NVTLEDTGYY
   121  NLQVTYRNSQ IEQASHHLRV YESVAQPSIQ ASSTTVTEKG SVVLTCHTNN TGTSFQWIFN
   181  NQRLQVTKRM KLSWFNHVLT IDPIRQEDAG EYQCEVSNPV SSNRSDPLKL TVKSDDNTLG
   241  ILIGVLVGSL LVAALVCFLL LRKTGRASDQ SDFREQQPPA STPGHGPSDS SIS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEACAM21 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.4
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 17 nTPM
spleen: 9.9 nTPM
lymph node: 5 nTPM
midbrain: 4.6 nTPM
hypothalamus: 4 nTPM
lung: 3.7 nTPM

Single-cell type

microglia: 36 nCPM
megakaryocytes: 12 nCPM
nk-cells: 6.7 nCPM
hepatic stellate cells: 6.5 nCPM
other brain neurons: 5.3 nCPM
t-cells: 5.1 nCPM

Immune cell

neutrophil: 30 nTPM
gdT-cell: 30 nTPM
eosinophil: 27 nTPM
T-reg: 27 nTPM
memory CD4 T-cell: 26 nTPM
naive CD4 T-cell: 21 nTPM

Brain region

hypothalamus: 7.3 nTPM
midbrain: 5.1 nTPM
pons: 3.8 nTPM
medulla oblongata: 3.2 nTPM
spinal cord: 2.7 nTPM
thalamus: 2.4 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.7
gnomAD pLI: 0
gnomAD missense Z: -0.32
DepMap mean gene effect: 0.06
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

external side of plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEACAM21 as an antibody target. Whether an autoantibody or antibody against CEACAM21 could matter depends on whether native CEACAM21 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEACAM21 is annotated at the cell surface, where native CEACAM21 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CEACAM21 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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