Seroatlas · Human Serome Atlas

CEACAM19

Cell adhesion molecule CEACAM19

Also known as: CEA19_HUMAN, CEAL1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q7Z692
Gene: CEACAM19
Ensembl: ENSG00000186567
Chromosome: 19
Canonical length: 300 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Subcellular location: Nucleoplasm,Nucleoli,Mitochondria

OverviewNCBI Gene

Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

300 residues, UniProt reviewed canonical sequence.

>Q7Z692|CEACAM19
     1  MEIPMGTQGC FSKSLLLSAS ILVLWMLQGS QAALYIQKIP EQPQKNQDLL LSVQGVPDTF
    61  QDFNWYLGEE TYGGTRLFTY IPGIQRPQRD GSAMGQRDIV GFPNGSMLLR RAQPTDSGTY
   121  QVAITINSEW TMKAKTEVQV AEKNKELPST HLPTNAGILA ATIIGSLAAG ALLISCIAYL
   181  LVTRNWRGQS HRLPAPRGQG SLSILCSAVS PVPSVTPSTW MATTEKPELG PAHDAGDNNI
   241  YEVMPSPVLL VSPISDTRSI NPARPLPTPP HLQAEPENHQ YQQDLLNPDP APYCQLVPTS

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CEACAM19 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Unknown
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 13 nTPM

Expression across tissuesHPA

Tissue

skeletal muscle: 13 nTPM
skin: 12 nTPM
heart muscle: 11 nTPM
pancreas: 8.5 nTPM
liver: 8.3 nTPM
vagina: 8.2 nTPM

Single-cell type

podocytes: 148 nCPM
tuft cells: 58 nCPM
myonuclei: 37 nCPM
salivary myoepithelial cells: 28 nCPM
loop of henle epithelial cells: 25 nCPM
adrenal cortex cells: 24 nCPM

Immune cell

basophil: 0.3 nTPM
classical monocyte: 0.1 nTPM
naive B-cell: 0.1 nTPM
neutrophil: 0.1 nTPM
total PBMC: 0.1 nTPM
eosinophil: 0 nTPM

Brain region

cerebral cortex: 12 nTPM
cerebellum: 11 nTPM
white matter: 11 nTPM
hippocampal formation: 9.4 nTPM
hypothalamus: 9 nTPM
basal ganglia: 8.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.58
gnomAD pLI: 0
gnomAD missense Z: 0.47
DepMap mean gene effect: 0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CEACAM19 as an antibody target. Whether an autoantibody or antibody against CEACAM19 could matter depends on whether native CEACAM19 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CEACAM19 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CEACAM19 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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