CDK18
Cyclin-dependent kinase 18
Also known as: CDK18_HUMAN, PCTAIRE3, PCTK3
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q07002
- Gene
- CDK18
- Ensembl
- ENSG00000117266
- Chromosome
- 1
- Canonical length
- 474 aa
- Protein class
- Enzymes, Predicted intracellular proteins
- Subcellular location
- Actin filaments
OverviewNCBI Gene
Predicted to enable cyclin-dependent protein serine/threonine kinase activity. Involved in positive regulation of myelination. Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
474 residues, UniProt reviewed canonical sequence.
>Q07002|CDK18
1 MIMNKMKNFK RRFSLSVPRT ETIEESLAEF TEQFNQLHNR RNENLQLGPL GRDPPQECST
61 FSPTDSGEEP GQLSPGVQFQ RRQNQRRFSM EDVSKRLSLP MDIRLPQEFL QKLQMESPDL
121 PKPLSRMSRR ASLSDIGFGK LETYVKLDKL GEGTYATVFK GRSKLTENLV ALKEIRLEHE
181 EGAPCTAIRE VSLLKNLKHA NIVTLHDLIH TDRSLTLVFE YLDSDLKQYL DHCGNLMSMH
241 NVKIFMFQLL RGLAYCHHRK ILHRDLKPQN LLINERGELK LADFGLARAK SVPTKTYSNE
301 VVTLWYRPPD VLLGSTEYST PIDMWGVGCI HYEMATGRPL FPGSTVKEEL HLIFRLLGTP
361 TEETWPGVTA FSEFRTYSFP CYLPQPLINH APRLDTDGIH LLSSLLLYES KSRMSAEAAL
421 SHSYFRSLGE RVHQLEDTAS IFSLKEIQLQ KDPGYRGLAF QQPGRGKNRR QSIFLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CDK18 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.35
- Highest tissue expression
- 368 nTPM
Expression across tissuesHPA
Tissue
- spinal cord: 368 nTPM
- midbrain: 141 nTPM
- heart muscle: 117 nTPM
- hippocampal formation: 71 nTPM
- hypothalamus: 56 nTPM
- basal ganglia: 48 nTPM
Single-cell type
- oligodendrocytes: 553 nCPM
- renal collecting duct principal cells: 112 nCPM
- retinal amacrine cells: 74 nCPM
- pancreatic duct cells: 62 nCPM
- müller glia: 58 nCPM
- enterocytes: 51 nCPM
Immune cell
- intermediate monocyte: 0.4 nTPM
- myeloid DC: 0.2 nTPM
- classical monocyte: 0.1 nTPM
- MAIT T-cell: 0.1 nTPM
- NK-cell: 0.1 nTPM
- total PBMC: 0.1 nTPM
Brain region
- medulla oblongata: 316 nTPM
- white matter: 303 nTPM
- midbrain: 249 nTPM
- pons: 236 nTPM
- cerebellum: 235 nTPM
- basal ganglia: 209 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.11
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.48
- DepMap mean gene effect
- 0.02
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CDK18 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CDK18 as an antibody target. Whether an autoantibody or antibody against CDK18 could matter depends on whether native CDK18 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CDK18 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CDK18 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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