Seroatlas · Human Serome Atlas

CDHR4

Cadherin-related family member 4

Also known as: CDH29, CDHR4_HUMAN, VLLR9392

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6H8M9
Gene: CDHR4
Ensembl: ENSG00000187492
Chromosome: 3
Canonical length: 788 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Secretome location: Intracellular and membrane

OverviewNCBI Gene

Predicted to enable calcium ion binding activity. Predicted to be involved in cell adhesion. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

788 residues, UniProt reviewed canonical sequence.

>A6H8M9|CDHR4
     1  MVLLRLLVFL FAPVVSDLCS LPCFINVSES QGPGTVLQFL SFNCSSYTPT PTLELLNVQP
    61  PTTFFNPPSL ARWQGTYVGK LTLSSSAQLD ALMVNHYKVQ LKFTCGNHVM EGSLSVDVQR
   121  DLSHIQCAGQ FASPAGEMIQ VPETVTPGAR LYTLLLPGLE LHGAQMSIIS AQDLPHFPGP
   181  FSINEQGWLQ APSQGLLGQA QKVFQLQISV SFGQRQSCQG MVIVKVLPVP SSQVSFLEQA
   241  QNITIPENLA PGSEVVQVQA RGVDLRYEIL SPVPSPLFSI GRADGVVRTT TPLELARTSG
   301  TAVSRLQVKA FEQGQLWASA KLNLTMNVQL VNLWPPRCLP ALLVSQIPET APVGTVLNTL
   361  TCEDPDSVGA TLDYKLWFRS SSNPASLCLY DRVLEVNATL DCDTPGACFQ HAASILVLDG
   421  GQPQMTTEVP VLVMVTPINE FSPACAPRTF RVQEDAAPHT LLGSVVGTDM DYPHDNIEYY
   481  TSGGPTTFAV DRLSGEVHLL GPLDYEQQRL YRLTVLVIDH GQDQNPNHHL SGSCTITIEV
   541  EDVNDHAPEC EPPFQELTIY APLGRSVEVT KMSCQIPQEP QRLIYSYSIV GGNSQNRFIL
   601  QGAILVHSDL VLGPFWPEQP RTYELLICVA DAGPSTPHLS TTATIIVHLV PRRASTVATS
   661  THRTTVPSTM TPMLVTDTEA FWQPQPWFVV VLTATGALLL LALGWLLGRL LQGLAQLLQA
   721  PSKPAQALLL NSIQGTEGSI EGFLEAPKME MSQAPSSVMS LHFDGRAQDS RTGRDYLFNT
   781  HTGARRWL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CDHR4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.37
Highest tissue expression: 56 nTPM

Expression across tissuesHPA

Tissue

fallopian tube: 56 nTPM
lung: 7.4 nTPM
testis: 7.3 nTPM
cervix: 3.2 nTPM
endometrium: 1.6 nTPM
hypothalamus: 1.6 nTPM

Single-cell type

respiratory ciliated cells: 253 nCPM
epididymal efferent duct ciliated cells: 197 nCPM
fallopian tube ciliated cells: 180 nCPM
endometrial ciliated cells: 160 nCPM
ependymal cells: 40 nCPM
respiratory deuterosomal cells: 12 nCPM

Immune cell

total PBMC: 3.9 nTPM
classical monocyte: 2 nTPM
basophil: 1.7 nTPM
neutrophil: 1 nTPM
intermediate monocyte: 0.7 nTPM
myeloid DC: 0.7 nTPM

Brain region

midbrain: 13 nTPM
pons: 7.8 nTPM
medulla oblongata: 7.5 nTPM
spinal cord: 3.4 nTPM
choroid plexus: 3 nTPM
white matter: 2.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: 2.18
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CDHR4 as an antibody target. Whether an autoantibody or antibody against CDHR4 could matter depends on whether native CDHR4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CDHR4 is annotated at the cell surface, where native CDHR4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CDHR4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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