Cadherin domain-containing protein
IPR050971
Definition
This family of proteins includes components of intercellular desmosome junctions, which are critical for cell-cell adhesion. They interact with plaque proteins and intermediate filaments, playing a key role in maintaining tissue integrity. Some members are involved in the maintenance of planar cell polarity and inhibition of cell proliferation and differentiation. Others mediate calcium-dependent heterophilic interactions and are essential for normal sensory functions. These proteins typically contain cadherin domains that bind calcium ions to ensure structural rigidity and proper function.
10 human proteins with this domain
Each is a reviewed human protein in the Seroatlas serome and a potential autoantibody target; this domain groups them into one antibody-relevant category. Every entry links to its own record.
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