Seroatlas · Human Serome Atlas

CD8B

T-cell surface glycoprotein CD8 beta chain

Also known as: CD8B_HUMAN, CD8B1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P10966
Gene
CD8B
Ensembl
ENSG00000172116
Chromosome
2
Canonical length
210 aa
Protein class
CD markers, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane
Secretome location
Intracellular and membrane

OverviewNCBI Gene

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen, acting as a coreceptor, and the T-cell receptor on the T lymphocyte recognize antigens displayed by an antigen presenting cell (APC) in the context of class I MHC molecules. The functional coreceptor is either a homodimer composed of two alpha chains, or a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 beta chain isoforms. Multiple alternatively spliced transcript variants encoding distinct membrane associated or secreted isoforms have been described. A pseudogene, also located on chromosome 2, has been identified. [provided by RefSeq, May 2010]

Canonical amino-acid sequenceUniProt

210 residues, UniProt reviewed canonical sequence.

>P10966|CD8B
     1  MRPRLWLLLA AQLTVLHGNS VLQQTPAYIK VQTNKMVMLS CEAKISLSNM RIYWLRQRQA
    61  PSSDSHHEFL ALWDSAKGTI HGEEVEQEKI AVFRDASRFI LNLTSVKPED SGIYFCMIVG
   121  SPELTFGKGT QLSVVDFLPT TAQPTKKSTL KKRVCRLPRP ETQKGPLCSP ITLGLLVAGV
   181  LVLLVSLGVA IHLCCRRRRA RLRFMKQFYK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD8B can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
427 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 427 nTPM
  • cervix: 31 nTPM
  • lymph node: 24 nTPM
  • small intestine: 14 nTPM
  • tonsil: 14 nTPM
  • spleen: 12 nTPM

Single-cell type

  • t-cells: 154 nCPM
  • endometrial secretory cells: 46 nCPM
  • enterocytes: 10 nCPM
  • corticotrophs: 9.3 nCPM
  • enteric transient amplifying cells: 8.2 nCPM
  • paneth cells: 7.7 nCPM

Immune cell

  • naive CD8 T-cell: 1,058 nTPM
  • memory CD8 T-cell: 603 nTPM
  • total PBMC: 428 nTPM
  • MAIT T-cell: 80 nTPM
  • basophil: 42 nTPM
  • gdT-cell: 16 nTPM

Brain region

  • pons: 11 nTPM
  • hypothalamus: 5.5 nTPM
  • medulla oblongata: 5.4 nTPM
  • midbrain: 5.1 nTPM
  • cerebellum: 2.9 nTPM
  • cerebral cortex: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.43
gnomAD pLI
0
gnomAD missense Z
0.52

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD8B in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD8B as an antibody target. Whether an autoantibody or antibody against CD8B could matter depends on whether native CD8B is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD8B is annotated at the cell surface, where native CD8B is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD8B as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD8B. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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