CD80

Protein identityUniProt · HPA

UniProt accession

P33681

Gene

CD80

Ensembl

ENSG00000121594

Chromosome

3

Canonical length

288 aa

Protein class

CD markers, FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins

Secretome location

Intracellular and membrane

Quaternary structure

Homodimer

OverviewNCBI Gene

The protein encoded by this gene is a membrane receptor that is activated by the binding of CD28 or CTLA-4. The activated protein induces T-cell proliferation and cytokine production. This protein can act as a receptor for adenovirus subgroup B and may play a role in lupus neuropathy. [provided by RefSeq, Aug 2011]

Canonical amino-acid sequenceUniProt

288 residues, UniProt reviewed canonical sequence.

>P33681|CD80
     1  MGHTRRQGTS PSKCPYLNFF QLLVLAGLSH FCSGVIHVTK EVKEVATLSC GHNVSVEELA
    61  QTRIYWQKEK KMVLTMMSGD MNIWPEYKNR TIFDITNNLS IVILALRPSD EGTYECVVLK
   121  YEKDAFKREH LAEVTLSVKA DFPTPSISDF EIPTSNIRRI ICSTSGGFPE PHLSWLENGE
   181  ELNAINTTVS QDPETELYAV SSKLDFNMTT NHSFMCLIKY GHLRVNQTFN WNTTKQEHFP
   241  DNLLPSWAIT LISVNGIFVI CCLTYCFAPR CRERRRNERL RRESVRPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD80 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.39

Highest tissue expression

6.4 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CD80.

Disease | AutoantibodyPubMed

Conditions in which antibodies against CD80 are reported. Each links to that disease's full target list.

• Lupus Erythematosus, Systemic 4
• Lupus Nephritis 3

ReferencesPubMed · IEDB

Publications for CD80 from three distinct lines of evidence, kept separate because they answer different questions: whether antibodies are directed at the protein, whether a B-cell epitope has been mapped on it, and whether a T-cell epitope has. Each is labelled with its source.

Sources: PubMed — antigen-level antibody evidence from a custom retrieval. Records matching a controlled set of autoantibody terms (the MeSH descriptors Autoantibodies and Autoantigens, with title and abstract term variants) were obtained through NCBI E-utilities, and their titles and abstracts parsed for constructions that direct an antibody at a named protein rather than for co-occurrence. Captured names were resolved against UniProt nomenclature and each antigen adjudicated individually against the source text. Bibliographic records from PubMed and MeSH, U.S. National Library of Medicine; citation metrics from NIH iCite (Hutchins et al., PLoS Biology 2016). Titles link to PubMed; abstracts are not reproduced here. The NLM does not endorse this analysis.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.9

gnomAD pLI

0.01

gnomAD missense Z

0.75

DepMap mean gene effect

0.05

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell surface receptor signaling pathway
• cellular response to lipopolysaccharide
• immune response
• intracellular signal transduction
• negative regulation of T cell activation
• negative regulation of T cell mediated immunity
• negative regulation of T cell proliferation
• negative regulation of T cell receptor signaling pathway
• positive regulation of DNA-templated transcription
• positive regulation of granulocyte macrophage colony-stimulating factor production
• positive regulation of interleukin-2 production
• positive regulation of peptidyl-tyrosine phosphorylation
• positive regulation of signal transduction
• positive regulation of T cell proliferation
• positive regulation of T cell receptor signaling pathway
• positive regulation of T-helper 1 cell differentiation
• T cell activation
• T cell costimulation

Molecular functions

• coreceptor activity
• receptor ligand activity
• virus receptor activity

Cellular components

• cell surface
• external side of plasma membrane
• plasma membrane
• protein complex involved in cell adhesion

Protein domainsUniProt · Pfam · InterPro

• Immunoglobulin domain subtype
• Immunoglobulin-like domain
• Immunoglobulin V-set domain
• CD80-like, immunoglobulin C2-set
• Immunoglobulin-like fold
• Immunoglobulin-like domain superfamily
• T-cell Activation and Immune Regulation Protein
• Immunoglobulin V-set domain
• CD80-like C2-set immunoglobulin domain
• CD80, IgC-like domain
• CD80, immunoglobulin variable domain

KeywordsUniProt

• Cell membrane
• Disulfide bond
• Glycoprotein
• Host cell receptor for virus entry
• Host-virus interaction
• Immunoglobulin domain
• Lipoprotein
• Membrane
• Palmitate
• Phosphoprotein
• Receptor
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of CD80 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• CD28
• CD274
• CTLA4