Seroatlas · Human Serome Atlas

CD3G

T-cell surface glycoprotein CD3 gamma chain

Also known as: CD3-GAMMA, CD3G_HUMAN, CD3GAMMA

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P09693
Gene
CD3G
Ensembl
ENSG00000160654
Chromosome
11
Canonical length
182 aa
Protein class
CD markers, Disease related genes, FDA approved drug targets, Human disease related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Plasma membrane,Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

182 residues, UniProt reviewed canonical sequence.

>P09693|CD3G
     1  MEQGKGLAVL ILAIILLQGT LAQSIKGNHL VKVYDYQEDG SVLLTCDAEA KNITWFKDGK
    61  MIGFLTEDKK KWNLGSNAKD PRGMYQCKGS QNKSKPLQVY YRMCQNCIEL NAATISGFLF
   121  AEIVSIFVLA VGVYFIAGQD GVRQSRASDK QTLLPNDQLY QPLKDREDDQ YSHLQGNQLR
   181  RN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD3G can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.5
Highest tissue expression
88 nTPM

Expression across tissuesHPA

Tissue

  • thymus: 88 nTPM
  • lymph node: 26 nTPM
  • tonsil: 19 nTPM
  • spleen: 11 nTPM
  • appendix: 9.9 nTPM
  • skeletal muscle: 9.7 nTPM

Single-cell type

  • t-cells: 300 nCPM
  • nk-cells: 35 nCPM
  • thymocytes: 24 nCPM
  • pdcs: 9.6 nCPM
  • innate lymphoid cells: 7.7 nCPM
  • neutrophil progenitors: 6.8 nCPM

Immune cell

  • naive CD8 T-cell: 242 nTPM
  • gdT-cell: 229 nTPM
  • T-reg: 200 nTPM
  • memory CD8 T-cell: 196 nTPM
  • naive CD4 T-cell: 193 nTPM
  • memory CD4 T-cell: 187 nTPM

Brain region

  • white matter: 5.8 nTPM
  • cerebellum: 4.3 nTPM
  • cerebral cortex: 4.3 nTPM
  • choroid plexus: 4.2 nTPM
  • medulla oblongata: 4.1 nTPM
  • pons: 3.9 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CD3G.

Disease | AllUniProt

Conditions CD3G is implicated in, by any mechanism.

Disease | GeneticClinVar

22 pathogenic / likely-pathogenic of 180 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.22
gnomAD pLI
0
gnomAD missense Z
0.08
DepMap mean gene effect
0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD3G as an antibody target. Whether an autoantibody or antibody against CD3G could matter depends on whether native CD3G is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD3G is annotated at the cell surface, where native CD3G is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD3G as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CD3G. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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