CD300LB
CMRF35-like molecule 7
Also known as: CLM7, CLM7_HUMAN, TREM5
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- A8K4G0
- Gene
- CD300LB
- Ensembl
- ENSG00000178789
- Chromosome
- 17
- Canonical length
- 201 aa
- Protein class
- CD markers, Predicted intracellular proteins, Predicted membrane proteins
- Subcellular location
- Plasma membrane
OverviewNCBI Gene
CD300LB is a nonclassical activating receptor of the immunoglobulin (Ig) superfamily expressed on myeloid cells (Martinez-Barriocanal and Sayos, 2006 [PubMed 16920917]).[supplied by OMIM, Mar 2008]
Canonical amino-acid sequenceUniProt
201 residues, UniProt reviewed canonical sequence.
>A8K4G0|CD300LB
1 MWLPPALLLL SLSGCFSIQG PESVRAPEQG SLTVQCHYKQ GWETYIKWWC RGVRWDTCKI
61 LIETRGSEQG EKSDRVSIKD NQKDRTFTVT MEGLRRDDAD VYWCGIERRG PDLGTQVKVI
121 VDPEGAASTT ASSPTNSNMA VFIGSHKRNH YMLLVFVKVP ILLILVTAIL WLKGSQRVPE
181 EPGEQPIYMN FSEPLTKDMA TLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CD300LB can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Cell surface
- Secreted
- No
- Transmembrane segments
- 1
- Mean surface accessibility (rSASA)
- 0.44
- Highest tissue expression
- 7.7 nTPM
Expression across tissuesHPA
Tissue
- appendix: 7.7 nTPM
- bone marrow: 7.3 nTPM
- spleen: 3.5 nTPM
- urinary bladder: 2.4 nTPM
- gallbladder: 2 nTPM
- adipose tissue: 1.7 nTPM
Single-cell type
- monocytes: 54 nCPM
- cdc: 50 nCPM
- macrophages: 30 nCPM
- neutrophils: 15 nCPM
- monocyte progenitors: 8.4 nCPM
- pdcs: 7.8 nCPM
Immune cell
- eosinophil: 76 nTPM
- neutrophil: 33 nTPM
- classical monocyte: 32 nTPM
- myeloid DC: 25 nTPM
- plasmacytoid DC: 16 nTPM
- intermediate monocyte: 14 nTPM
Brain region
- cerebral cortex: 34 nTPM
- pons: 6.3 nTPM
- thalamus: 2.7 nTPM
- choroid plexus: 1.1 nTPM
- white matter: 0.7 nTPM
- medulla oblongata: 0.6 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.62
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.59
- DepMap mean gene effect
- -0.05
- DepMap dependency class
- none
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CD300LB in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CD300LB as an antibody target. Whether an autoantibody or antibody against CD300LB could matter depends on whether native CD300LB is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CD300LB is annotated at the cell surface, where native CD300LB is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.
Annotation status
The present source text does not explicitly label CD300LB as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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