Seroatlas · Human Serome Atlas

CD300E

CMRF35-like molecule 2

Also known as: CD300LE, CLM2, CLM2_HUMAN, IREM2

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q496F6
Gene: CD300E
Ensembl: ENSG00000186407
Chromosome: 17
Canonical length: 205 aa
Protein class: CD markers, Predicted intracellular proteins, Predicted membrane proteins

OverviewNCBI Gene

This gene encodes a member of the CD300 glycoprotein family of cell surface proteins expressed on myeloid cells. The protein interacts with the TYRO protein tyrosine kinase-binding protein and is thought to act as an activating receptor. [provided by RefSeq, Nov 2012]

Canonical amino-acid sequenceUniProt

205 residues, UniProt reviewed canonical sequence.

>Q496F6|CD300E
     1  MWLLPALLLL CLSGCLSLKG PGSVTGTAGD SLTVWCQYES MYKGYNKYWC RGQYDTSCES
    61  IVETKGEEKV ERNGRVSIRD HPEALAFTVT MQNLNEDDAG SYWCKIQTVW VLDSWSRDPS
   121  DLVRVYVSPA ITTPRRTTHP ATPPIFLVVN PGRNLSTGEV LTQNSGFRLS SPHFLLVVLL
   181  KLPLLLSMLG AVFWVNRPQW APPGR

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD300E can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 45 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 45 nTPM
appendix: 35 nTPM
urinary bladder: 17 nTPM
lung: 16 nTPM
adipose tissue: 13 nTPM
spleen: 10 nTPM

Single-cell type

monocytes: 332 nCPM
cdc: 36 nCPM
macrophages: 31 nCPM
neutrophils: 16 nCPM
platelets: 7 nCPM
retinal amacrine cells: 4.8 nCPM

Immune cell

non-classical monocyte: 149 nTPM
intermediate monocyte: 135 nTPM
classical monocyte: 88 nTPM
total PBMC: 54 nTPM
myeloid DC: 22 nTPM
neutrophil: 1.9 nTPM

Brain region

thalamus: 9.1 nTPM
choroid plexus: 6.2 nTPM
cerebral cortex: 4.7 nTPM
cerebellum: 3.8 nTPM
pons: 2.7 nTPM
amygdala: 2.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0.02
gnomAD missense Z: 0.53
DepMap mean gene effect: -0.1
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

transmembrane signaling receptor activity

Cellular components

plasma membrane

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CD300E in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

TYROBP

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD300E as an antibody target. Whether an autoantibody or antibody against CD300E could matter depends on whether native CD300E is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD300E is annotated at the cell surface, where native CD300E is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD300E as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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