Seroatlas · Human Serome Atlas

CD101

Immunoglobulin superfamily member 2

Also known as: IGSF2, IGSF2_HUMAN, V7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q93033
Gene: CD101
Ensembl: ENSG00000134256
Chromosome: 1
Canonical length: 1021 aa
Protein class: CD markers, Predicted membrane proteins
Subcellular location: Mitochondria

OverviewNCBI Gene

Predicted to enable hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides. Predicted to be involved in cell surface receptor signaling pathway. Predicted to act upstream of or within positive regulation of myeloid leukocyte differentiation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

1021 residues, UniProt reviewed canonical sequence.

>Q93033|CD101
     1  MAGISYVASF FLLLTKLSIG QREVTVQKGP LFRAEGYPVS IGCNVTGHQG PSEQHFQWSV
    61  YLPTNPTQEV QIISTKDAAF SYAVYTQRVR SGDVYVERVQ GNSVLLHISK LQMKDAGEYE
   121  CHTPNTDEKY YGSYSAKTNL IVIPDTLSAT MSSQTLGKEE GEPLALTCEA SKATAQHTHL
   181  SVTWYLTQDG GGSQATEIIS LSKDFILVPG PLYTERFAAS DVQLNKLGPT TFRLSIERLQ
   241  SSDQGQLFCE ATEWIQDPDE TWMFITKKQT DQTTLRIQPA VKDFQVNITA DSLFAEGKPL
   301  ELVCLVVSSG RDPQLQGIWF FNGTEIAHID AGGVLGLKND YKERASQGEL QVSKLGPKAF
   361  SLKIFSLGPE DEGAYRCVVA EVMKTRTGSW QVLQRKQSPD SHVHLRKPAA RSVVMSTKNK
   421  QQVVWEGETL AFLCKAGGAE SPLSVSWWHI PRDQTQPEFV AGMGQDGIVQ LGASYGVPSY
   481  HGNTRLEKMD WATFQLEITF TAITDSGTYE CRVSEKSRNQ ARDLSWTQKI SVTVKSLESS
   541  LQVSLMSRQP QVMLTNTFDL SCVVRAGYSD LKVPLTVTWQ FQPASSHIFH QLIRITHNGT
   601  IEWGNFLSRF QKKTKVSQSL FRSQLLVHDA TEEETGVYQC EVEVYDRNSL YNNRPPRASA
   661  ISHPLRIAVT LPESKLKVNS RSQVQELSIN SNTDIECSIL SRSNGNLQLA IIWYFSPVST
   721  NASWLKILEM DQTNVIKTGD EFHTPQRKQK FHTEKVSQDL FQLHILNVED SDRGKYHCAV
   781  EEWLLSTNGT WHKLGEKKSG LTELKLKPTG SKVRVSKVYW TENVTEHREV AIRCSLESVG
   841  SSATLYSVMW YWNRENSGSK LLVHLQHDGL LEYGEEGLRR HLHCYRSSST DFVLKLHQVE
   901  MEDAGMYWCR VAEWQLHGHP SKWINQASDE SQRMVLTVLP SEPTLPSRIC SSAPLLYFLF
   961  ICPFVLLLLL LISLLCLYWK ARKLSTLRSN TRKEKALWVD LKEAGGVTTN RREDEEEDEG
  1021  N

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CD101 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.32
Highest tissue expression: 6.3 nTPM

Expression across tissuesHPA

Tissue

lung: 6.3 nTPM
small intestine: 5.9 nTPM
bone marrow: 4.4 nTPM
duodenum: 3.4 nTPM
appendix: 3.1 nTPM
spleen: 2.9 nTPM

Single-cell type

neutrophil progenitors: 25 nCPM
salivary basal cells: 17 nCPM
t-cells: 15 nCPM
breast lactating cells: 14 nCPM
salivary myoepithelial cells: 13 nCPM
kupffer cells: 12 nCPM

Immune cell

eosinophil: 97 nTPM
non-classical monocyte: 53 nTPM
myeloid DC: 34 nTPM
intermediate monocyte: 27 nTPM
classical monocyte: 21 nTPM
total PBMC: 7.6 nTPM

Brain region

cerebral cortex: 1.1 nTPM
white matter: 0.9 nTPM
basal ganglia: 0.8 nTPM
medulla oblongata: 0.8 nTPM
spinal cord: 0.8 nTPM
amygdala: 0.7 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.85
gnomAD pLI: 0
gnomAD missense Z: 0.36
DepMap mean gene effect: -0.24
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

in cyclic amides
hydrolase activity
acting on carbon-nitrogen (but not peptide) bonds

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CD101 as an antibody target. Whether an autoantibody or antibody against CD101 could matter depends on whether native CD101 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CD101 is annotated at the cell surface, where native CD101 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CD101 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...