Seroatlas · Human Serome Atlas

CCDC86

Coiled-coil domain-containing protein 86

Also known as: CCD86_HUMAN, cyclon, MGC2574

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H6F5
Gene: CCDC86
Ensembl: ENSG00000110104
Chromosome: 11
Canonical length: 360 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nucleoli,Nucleoli rim,Mitotic chromosome

OverviewNCBI Gene

Enables RNA binding activity. Located in chromosome; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

360 residues, UniProt reviewed canonical sequence.

>Q9H6F5|CCDC86
     1  MDTPLRRSRR LGGLRPESPE SLTSVSRTRR ALVEFESNPE ETREPGSPPS VQRAGLGSPE
    61  RPPKTSPGSP RLQQGAGLES PQGQPEPGAA SPQRQQDLHL ESPQRQPEYS PESPRCQPKP
   121  SEEAPKCSQD QGVLASELAQ NKEELTPGAP QHQLPPVPGS PEPYPGQQAP GPEPSQPLLE
   181  LTPRAPGSPR GQHEPSKPPP AGETVTGGFG AKKRKGSSSQ APASKKLNKE ELPVIPKGKP
   241  KSGRVWKDRS KKRFSQMLQD KPLRTSWQRK MKERQERKLA KDFARHLEEE KERRRQEKKQ
   301  RRAENLKRRL ENERKAEVVQ VIRNPAKLKR AKKKQLRSIE KRDTLALLQK QPPQQPAAKI

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC86 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.69
Highest tissue expression: 355 nTPM

Expression across tissuesHPA

Tissue

parathyroid gland: 355 nTPM
testis: 47 nTPM
skeletal muscle: 33 nTPM
adrenal gland: 26 nTPM
adipose tissue: 24 nTPM
pituitary gland: 23 nTPM

Single-cell type

late primary spermatocytes: 128 nCPM
oocytes: 41 nCPM
esophageal basal cells: 41 nCPM
basal keratinocytes: 31 nCPM
migrating cytotrophoblasts: 29 nCPM
differentiating spermatogonia: 25 nCPM

Immune cell

myeloid DC: 30 nTPM
intermediate monocyte: 29 nTPM
plasmacytoid DC: 17 nTPM
classical monocyte: 14 nTPM
naive CD4 T-cell: 12 nTPM
naive CD8 T-cell: 10 nTPM

Brain region

pons: 16 nTPM
white matter: 16 nTPM
midbrain: 16 nTPM
hypothalamus: 16 nTPM
medulla oblongata: 15 nTPM
cerebral cortex: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.02
gnomAD pLI: 0
gnomAD missense Z: 0.48
DepMap mean gene effect: -0.62
DepMap dependency class: common

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

RNA binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 86

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC86 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NPM1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC86 as an antibody target. Whether an autoantibody or antibody against CCDC86 could matter depends on whether native CCDC86 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC86 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC86 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Loading the interactive Seroatlas protein explorer...