Seroatlas · Human Serome Atlas

CCDC85A

Coiled-coil domain-containing protein 85A

Also known as: CC85A_HUMAN, KIAA1912

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q96PX6
Gene: CCDC85A
Ensembl: ENSG00000055813
Chromosome: 2
Canonical length: 553 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Located in adherens junction. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

553 residues, UniProt reviewed canonical sequence.

>Q96PX6|CCDC85A
     1  MSKAAGGAAA AAAAAESCSP APAGSSAAPP APVEDLSKVS DEELLQWSKE ELIRSLRRAE
    61  AEKVSAMLDH SNLIREVNRR LQLHLGEIRG LKDINQKLQE DNQELRDLCC FLDDDRQKGK
   121  RVSREWQRLG RYTAGVMHKE VALYLQKLKD LEVKQEEVVK ENMELKELCV LLDEEKGAGC
   181  AGSRCSIDSQ ASLCQLTAST APYVRDVGDG SSTSSTGSTD SPDHHKHHAS SGSPEHLQKP
   241  RSEGSPEHSK HRSASPEHPQ KPRACGTPDR PKALKGPSPE HHKPLCKGSP EQQRHPHPGS
   301  SPETLPKHVL SGSPEHFQKH RSGSSPEHAR HSGGSPEHLQ KHALGGSLEH LPRARGTSPE
   361  HLKQHYGGSP DHKHGGGSGG SGGSGGGSRE GTLRRQAQED GSPHHRNVYS GMNESTLSYV
   421  RQLEARVRQL EEENRMLPQA SQNRRQPPTR NSSNMEKGWG SRARRVLQWW QGCRGIGRCL
   481  PTLPGSFRLS SGADGSNSSP NSAASFSGHA TPSQQPEPVV HSLKVVWRKL GDAAGSCPGI
   541  RQHLSGNQYK GPM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC85A can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.61
Highest tissue expression: 12 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 12 nTPM
adipose tissue: 12 nTPM
placenta: 9.4 nTPM
thyroid gland: 8.6 nTPM
tongue: 7 nTPM
endometrium: 5.9 nTPM

Single-cell type

brain excitatory neurons: 236 nCPM
brain inhibitory neurons: 192 nCPM
other brain neurons: 182 nCPM
choroid plexus epithelial cells: 103 nCPM
astrocytes: 70 nCPM
oligodendrocyte progenitor cells: 48 nCPM

Immune cell

memory B-cell: 0.3 nTPM
basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM

Brain region

medulla oblongata: 50 nTPM
white matter: 44 nTPM
spinal cord: 37 nTPM
cerebral cortex: 28 nTPM
hypothalamus: 28 nTPM
basal ganglia: 27 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.89
gnomAD pLI: 0
gnomAD missense Z: -0.21
DepMap mean gene effect: -0.03
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

adherens junction

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC85A in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NEK2

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC85A as an antibody target. Whether an autoantibody or antibody against CCDC85A could matter depends on whether native CCDC85A is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC85A is annotated at the cell surface, where native CCDC85A is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CCDC85A as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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