Seroatlas · Human Serome Atlas

CCDC51

Mitochondrial potassium channel

Also known as: FLJ12436, MITOK_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96ER9
Gene
CCDC51
Ensembl
ENSG00000164051
Chromosome
3
Canonical length
411 aa
Protein class
FDA approved drug targets, Predicted intracellular proteins, Predicted membrane proteins
Subcellular location
Nucleoplasm,Centrosome,Mitochondria

OverviewNCBI Gene

Enables mitochondrial ATP-gated potassium channel activity. Involved in cell volume homeostasis and mitochondrial potassium ion transmembrane transport. Located in mitochondrial inner membrane. Part of mitochondrial ATP-gated potassium channel complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

411 residues, UniProt reviewed canonical sequence.

>Q96ER9|CCDC51
     1  MMGRSPGFAM QHIVGVPHVL VRRGLLGRDL FMTRTLCSPG PSQPGEKRPE EVALGLHHRL
    61  PALGRALGHS IQQRATSTAK TWWDRYEEFV GLNEVREAQG KVTEAEKVFM VARGLVREAR
   121  EDLEVHQAKL KEVRDRLDRV SREDSQYLEL ATLEHRMLQE EKRLRTAYLR AEDSEREKFS
   181  LFSAAVRESH EKERTRAERT KNWSLIGSVL GALIGVAGST YVNRVRLQEL KALLLEAQKG
   241  PVSLQEAIRE QASSYSRQQR DLHNLMVDLR GLVHAAGPGQ DSGSQAGSPP TRDRDVDVLS
   301  AALKEQLSHS RQVHSCLEGL REQLDGLEKT CSQMAGVVQL VKSAAHPGLV EPADGAMPSF
   361  LLEQGSMILA LSDTEQRLEA QVNRNTIYST LVTCVTFVAT LPVLYMLFKA S

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC51 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
2
Mean surface accessibility (rSASA)
0.51
Highest tissue expression
60 nTPM

Expression across tissuesHPA

Tissue

  • choroid plexus: 60 nTPM
  • kidney: 15 nTPM
  • skeletal muscle: 15 nTPM
  • esophagus: 13 nTPM
  • adrenal gland: 13 nTPM
  • rectum: 13 nTPM

Single-cell type

  • retinal pigment epithelial cells: 81 nCPM
  • migrating cytotrophoblasts: 54 nCPM
  • cytotrophoblasts: 47 nCPM
  • esophageal basal cells: 36 nCPM
  • gastric progenitor cells: 36 nCPM
  • alveolar cells type 1: 29 nCPM

Immune cell

  • memory B-cell: 28 nTPM
  • myeloid DC: 26 nTPM
  • naive B-cell: 23 nTPM
  • plasmacytoid DC: 21 nTPM
  • T-reg: 20 nTPM
  • memory CD8 T-cell: 20 nTPM

Brain region

  • choroid plexus: 33 nTPM
  • thalamus: 10 nTPM
  • cerebral cortex: 9.7 nTPM
  • medulla oblongata: 9.4 nTPM
  • pons: 9.2 nTPM
  • hippocampal formation: 8.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.17
gnomAD pLI
0
gnomAD missense Z
1.08
DepMap mean gene effect
-0.25
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

  • mitochondrial ATP-gated potassium channel activity

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Coiled-coil domain-containing protein 51

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC51 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC51 as an antibody target. Whether an autoantibody or antibody against CCDC51 could matter depends on whether native CCDC51 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC51 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC51 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CCDC51. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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