Seroatlas · Human Serome Atlas

CCDC158

Coiled-coil domain-containing protein 158

Also known as: CD158_HUMAN, FLJ25770

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q5M9N0
Gene: CCDC158
Ensembl: ENSG00000163749
Chromosome: 4
Canonical length: 1113 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

No narrative summary is available for CCDC158 in this catalog release; identity and structured annotations are shown without generated factual claims.

Canonical amino-acid sequenceUniProt

1113 residues, UniProt reviewed canonical sequence.

>Q5M9N0|CCDC158
     1  MESKAWESNN EDLLSSSGVT SNGGSSSSFF VSSIRGTIIE NTSSAGTLTQ VPFFPKYEVE
    61  LDSPRKIIPS PGKEHFERVL EEYSHQVKDL QRRLNESNEL HEKQKFYLRQ SVIDLQTKLQ
   121  EMQMERDAMA DIRRRESQSQ EDLRNQLQNT VHELEAAKCL KEDMLKDSNT QIEQLRKMML
   181  SHEGVLQEIR SILVDFEEAS GKKICEHDSM STLHFRSLGS AISKILRELD TEISYLKGRI
   241  FPVEDQLEAL KSESQNKIEL LLQQHQDRIE QLISEHEVEI TGLTEKASSA RSQANSIQSQ
   301  MEIIQEQARN QNSMYMRQLS DLESTVSQLR SELREAKRMY EDKTEELEKQ LVLANSELTE
   361  ARTERDQFSQ ESGNLDDQLQ KLLADLHKRE KELSLEKEQN KRLWDRDTGN SITIDHLRRE
   421  LDNRNMEVQR LEALLKALKS ECQGQMERQM AAIQGKNESL EKVSSLTAQL ESTKEMLRKV
   481  VEELTAKKMT LESSERTISD LTTSLQEKER AIEATNAEIT KLRSRVDLKL QELQHLKNEG
   541  DHLRNVQTEC EALKLQMTEK DKVIEILRQQ IENMTQLVGQ HGRTAGAMQV EKAQLEKEIN
   601  DRRMELKELK ILKDKKDAKI RELEARVSDL ELEKVKLVNA GSERLRAVKD IKQERDQLLN
   661  EVKTSRSELN NLSEEYEVLK RNFRNKSEEM EMTTNKLKMQ LKSAQSELEQ TRNTLKSMEG
   721  SDGHAMKVAM GMQKQITAKR GQIDALQSKI QFLEEAMTNA NKEKHFLKEE KSKLSQELST
   781  VATEKNKMAG ELEVLRSQER RLKEKVTNME VALDKASLQF AECQDIIQRQ EQESVRLKLQ
   841  HTLDIKELQG PGYTSNSSLK PRLLQPASVT RSHSNVPSSQ STASFLSHHS TKANTLKEDP
   901  TRDLKQLLQE LRSVINEEPA VSLSKTEEDG RTSLGALEDR VRDCITESSL RSDMCHRSNN
   961  SLRDSTEGSK SSETLSREPV TLHAGDREDP SGCFTFTSAA SPSVKNSASR SFNSSPKKSP
  1021  VHSLLTSSVE GSIGSTSQYR SAKPIHSSDS VKDSQSPPIE TTGKTCRKLQ NRLESLQTLV
  1081  EDLQLKNQAM SSMIRNQEKR IQKVKDQEKM LLK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CCDC158 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.53
Highest tissue expression: 32 nTPM

Expression across tissuesHPA

Tissue

testis: 32 nTPM
liver: 1.5 nTPM
thyroid gland: 1.2 nTPM
breast: 1.1 nTPM
epididymis: 0.9 nTPM
adipose tissue: 0.5 nTPM

Single-cell type

late primary spermatocytes: 170 nCPM
late spermatids: 144 nCPM
gonadotrophs: 74 nCPM
early spermatids: 71 nCPM
early primary spermatocytes: 58 nCPM
pituicytes/fscs: 30 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

hypothalamus: 3 nTPM
midbrain: 2.9 nTPM
cerebral cortex: 2.6 nTPM
medulla oblongata: 2.6 nTPM
spinal cord: 2.6 nTPM
white matter: 2.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.97
gnomAD pLI: 0
gnomAD missense Z: -0.23
DepMap mean gene effect: -0.13
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

receptor-mediated endocytosis

Molecular functions

clathrin binding

Cellular components

Protein domainsUniProt · Pfam · InterPro

Coiled-coil domain-containing protein 158
Coiled-coil domain-containing protein 158

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CCDC158 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CCDC158 as an antibody target. Whether an autoantibody or antibody against CCDC158 could matter depends on whether native CCDC158 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CCDC158 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CCDC158 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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