CCDC124
Coiled-coil domain-containing protein 124
Also known as: CC124_HUMAN, Lso2, oxs1
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96CT7
- Gene
- CCDC124
- Ensembl
- ENSG00000007080
- Chromosome
- 19
- Canonical length
- 223 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Plasma membrane,Cytosol
OverviewNCBI Gene
Enables RNA binding activity. Predicted to be involved in transcription by RNA polymerase II. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
223 residues, UniProt reviewed canonical sequence.
>Q96CT7|CCDC124
1 MPKKFQGENT KSAAARARRA EAKAAADAKK QKELEDAYWK DDDKHVMRKE QRKEEKEKRR
61 LDQLERKKET QRLLEEEDSK LKGGKAPRVA TSSKVTRAQI EDTLRRDHQL REAPDTAEKA
121 KSHLEVPLEE NVNRRVLEEG SVEARTIEDA IAVLSVAEEA ADRHPERRMR AAFTAFEEAQ
181 LPRLKQENPN MRLSQLKQLL KKEWLRSPDN PMNQRAVPFN APKLocalizationUniProt · AlphaFold · HPA
Whether an antibody against CCDC124 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Intracellular
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.52
- Highest tissue expression
- 196 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 196 nTPM
- cerebral cortex: 134 nTPM
- amygdala: 124 nTPM
- heart muscle: 122 nTPM
- midbrain: 115 nTPM
- hippocampal formation: 114 nTPM
Single-cell type
- esophageal apical cells: 299 nCPM
- esophageal suprabasal cells: 182 nCPM
- late spermatids: 182 nCPM
- extravillous trophoblasts: 166 nCPM
- esophageal basal cells: 141 nCPM
- migrating cytotrophoblasts: 129 nCPM
Immune cell
- intermediate monocyte: 95 nTPM
- gdT-cell: 86 nTPM
- myeloid DC: 86 nTPM
- T-reg: 84 nTPM
- classical monocyte: 82 nTPM
- basophil: 81 nTPM
Brain region
- thalamus: 87 nTPM
- white matter: 87 nTPM
- cerebral cortex: 85 nTPM
- pons: 84 nTPM
- cerebellum: 81 nTPM
- medulla oblongata: 80 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.8
- gnomAD pLI
- 0.28
- gnomAD missense Z
- 0.76
- DepMap mean gene effect
- -0.06
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 7% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Biological processes
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
- Coiled-coil domain-containing protein 124/Oxs1
- Coiled-coil domain-containing protein 124/Oxs1, C-terminal
- Coiled-coil domain-containing protein 124 /Oxs1
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of CCDC124 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads CCDC124 as an antibody target. Whether an autoantibody or antibody against CCDC124 could matter depends on whether native CCDC124 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
CCDC124 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label CCDC124 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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