Seroatlas · Human Serome Atlas

CBLN4

Cerebellin-4

Also known as: CBLN4_HUMAN, CBLNL1, dJ885A10.1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9NTU7
Gene: CBLN4
Ensembl: ENSG00000054803
Chromosome: 20
Canonical length: 201 aa
Protein class: Plasma proteins, Predicted secreted proteins
Subcellular location: Cytosol,Perinuclear theca,Calyx,Flagellar centriole,Mid piece,Principal piece
Secretome location: Secreted in brain
Quaternary structure: Homohexamer

OverviewNCBI Gene

This gene encodes a member of a family of small secreted proteins containing C1Q domains. Members of this family are involved in regulation of neurexin signalling during synapse development. The mouse homolog of the protein encoded by this gene competes with netrin to bind to the deleted in colorectal cancer receptor. [provided by RefSeq, Aug 2012]

Canonical amino-acid sequenceUniProt

201 residues, UniProt reviewed canonical sequence.

>Q9NTU7|CBLN4
     1  MGSGRRALSA VPAVLLVLTL PGLPVWAQND TEPIVLEGKC LVVCDSNPAT DSKGSSSSPL
    61  GISVRAANSK VAFSAVRSTN HEPSEMSNKT RIIYFDQILV NVGNFFTLES VFVAPRKGIY
   121  SFSFHVIKVY QSQTIQVNLM LNGKPVISAF AGDKDVTREA ATNGVLLYLD KEDKVYLKLE
   181  KGNLVGGWQY STFSGFLVFP L

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CBLN4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Secreted
Secreted: Yes
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.39
Highest tissue expression: 17 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 17 nTPM
cerebral cortex: 16 nTPM
hypothalamus: 13 nTPM
epididymis: 8.3 nTPM
basal ganglia: 8 nTPM
amygdala: 7.5 nTPM

Single-cell type

peritubular myoid cells: 44 nCPM
other brain neurons: 29 nCPM
brain inhibitory neurons: 22 nCPM
epididymal basal cells: 21 nCPM
brain excitatory neurons: 16 nCPM
fibro-adipogenic progenitors: 7.4 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

midbrain: 46 nTPM
cerebral cortex: 40 nTPM
amygdala: 40 nTPM
thalamus: 33 nTPM
hypothalamus: 28 nTPM
basal ganglia: 15 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1
gnomAD pLI: 0.17
gnomAD missense Z: 1.96
DepMap mean gene effect: -0.08
DepMap dependency class: none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CBLN4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CBLN4 as an antibody target. Whether an autoantibody or antibody against CBLN4 could matter depends on whether native CBLN4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CBLN4 is annotated as secreted, so native CBLN4 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.

Annotation status

The present source text does not explicitly label CBLN4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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