CASP6

Protein identityUniProt · HPA

UniProt accession

P55212

Gene

CASP6

Ensembl

ENSG00000138794

Chromosome

4

Canonical length

293 aa

Protein class

Cancer-related genes, Enzymes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Cytosol

OverviewNCBI Gene

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family of enzymes. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic acid residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein is processed by caspases 7, 8 and 10, and is thought to function as a downstream enzyme in the caspase activation cascade. Alternative splicing of this gene results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Oct 2015]

Canonical amino-acid sequenceUniProt

293 residues, UniProt reviewed canonical sequence.

>P55212|CASP6
     1  MSSASGLRRG HPAGGEENMT ETDAFYKREM FDPAEKYKMD HRRRGIALIF NHERFFWHLT
    61  LPERRGTCAD RDNLTRRFSD LGFEVKCFND LKAEELLLKI HEVSTVSHAD ADCFVCVFLS
   121  HGEGNHIYAY DAKIEIQTLT GLFKGDKCHS LVGKPKIFII QACRGNQHDV PVIPLDVVDN
   181  QTEKLDTNIT EVDAASVYTL PAGADFLMCY SVAEGYYSHR ETVNGSWYIQ DLCEMLGKYG
   241  SSLEFTELLT LVNRKVSQRR VDFCKDPSAI GKKQVPCFAS MLTKKLHFFP KSN

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CASP6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Intracellular

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.3

Highest tissue expression

38 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.09

gnomAD pLI

0

gnomAD missense Z

0.8

DepMap mean gene effect

0.01

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• activation of innate immune response
• apoptotic process
• cellular response to staurosporine
• epithelial cell differentiation
• hepatocyte apoptotic process
• intrinsic apoptotic signaling pathway by p53 class mediator
• positive regulation of apoptotic process
• positive regulation of necroptotic process
• positive regulation of neuron apoptotic process
• protein autoprocessing
• proteolysis
• pyroptotic inflammatory response
• regulation of programmed cell death

Molecular functions

• cysteine-type endopeptidase activity
• cysteine-type peptidase activity
• identical protein binding

Cellular components

• cytoplasm
• cytosol
• nucleoplasm
• nucleus

Protein domainsUniProt · Pfam · InterPro

• Peptidase C14, p20 domain
• Peptidase C14, caspase non-catalytic subunit p10
• Peptidase C14 family
• Peptidase C14, caspase domain
• Peptidase C14A, caspase catalytic domain
• Peptidase family C14A, His active site
• Caspase-like domain superfamily
• Peptidase family C14A, cysteine active site
• Caspase domain

KeywordsUniProt

• Apoptosis
• Autocatalytic cleavage
• Cytoplasm
• Hydrolase
• Lipoprotein
• Nucleus
• Palmitate
• Phosphoprotein
• Protease
• Thiol protease
• Zymogen

InteractionsUniProt · HPA

Protein binding partners of CASP6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RIPK3
• CASP3