CAP2

Protein identityUniProt · HPA

UniProt accession

P40123

Gene

CAP2

Ensembl

ENSG00000112186

Chromosome

6

Canonical length

477 aa

Protein class

Cancer-related genes, Predicted intracellular proteins

Subcellular location

Nucleoplasm,Plasma membrane,Cytosol

OverviewNCBI Gene

This gene was identified by its similarity to the gene for human adenylyl cyclase-associated protein. The function of the protein encoded by this gene is unknown. However, the protein appears to be able to interact with adenylyl cyclase-associated protein and actin. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

477 residues, UniProt reviewed canonical sequence.

>P40123|CAP2
     1  MANMQGLVER LERAVSRLES LSAESHRPPG NCGEVNGVIA GVAPSVEAFD KLMDSMVAEF
    61  LKNSRILAGD VETHAEMVHS AFQAQRAFLL MASQYQQPHE NDVAALLKPI SEKIQEIQTF
   121  RERNRGSNMF NHLSAVSESI PALGWIAVSP KPGPYVKEMN DAATFYTNRV LKDYKHSDLR
   181  HVDWVKSYLN IWSELQAYIK EHHTTGLTWS KTGPVASTVS AFSVLSSGPG LPPPPPPLPP
   241  PGPPPLFENE GKKEESSPSR SALFAQLNQG EAITKGLRHV TDDQKTYKNP SLRAQGGQTQ
   301  SPTKSHTPSP TSPKSYPSQK HAPVLELEGK KWRVEYQEDR NDLVISETEL KQVAYIFKCE
   361  KSTIQIKGKV NSIIIDNCKK LGLVFDNVVG IVEVINSQDI QIQVMGRVPT ISINKTEGCH
   421  IYLSEDALDC EIVSAKSSEM NILIPQDGDY REFPIPEQFK TAWDGSKLIT EPAEIMA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAP2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

0

Mean surface accessibility (rSASA)

0.38

Highest tissue expression

540 nTPM

Expression across tissuesHPA

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CAP2.

Disease | AllUniProt

Conditions CAP2 is implicated in, by any mechanism.

• Cardiomyopathy, dilated, 2I (CMD2I) MIM:620462

Disease | GeneticClinVar

4 pathogenic / likely-pathogenic of 86 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

• Cardiomyopathy, dilated, 2I

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.41

gnomAD pLI

0.7

gnomAD missense Z

1.1

DepMap mean gene effect

0.08

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• actin filament organization
• activation of adenylate cyclase activity
• cAMP-mediated signaling
• cell morphogenesis
• establishment or maintenance of cell polarity
• presynaptic actin cytoskeleton organization
• signal transduction

Molecular functions

• actin binding
• adenylate cyclase binding
• identical protein binding

Cellular components

• cytoplasm
• plasma membrane
• postsynaptic density

Protein domainsUniProt · Pfam · InterPro

• Adenylate cyclase-associated CAP
• CARP motif
• Adenylate cyclase-associated CAP, C-terminal
• Adenylate cyclase-associated CAP, N-terminal
• Cyclase-associated protein CAP/septum formation inhibitor MinC, C-terminal
• C-CAP/cofactor C-like domain
• CAP, conserved site, N-terminal
• CAP, conserved site, C-terminal
• Adenylate cyclase-associated CAP, N-terminal domain superfamily
• Adenylate cyclase-associated CAP, C-terminal superfamily
• CAP, N-terminal domain
• CAP N-terminal conserved motif
• Adenylate cyclase associated (CAP) C terminal
• CAP, N-terminal domain

KeywordsUniProt

• Acetylation
• Cardiomyopathy
• Cell membrane
• Membrane
• Phosphoprotein

InteractionsUniProt · HPA

Protein binding partners of CAP2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• ACTA1
• ACTB
• ACTG1
• CFL1