Seroatlas · Human Serome Atlas

CAP1

Adenylyl cyclase-associated protein 1

Also known as: CAP, CAP1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q01518
Gene
CAP1
Ensembl
ENSG00000131236
Chromosome
1
Canonical length
475 aa
Protein class
Plasma proteins, Predicted intracellular proteins
Subcellular location
Cytosol
Quaternary structure
Homodimer

OverviewNCBI Gene

The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2016]

Canonical amino-acid sequenceUniProt

475 residues, UniProt reviewed canonical sequence.

>Q01518|CAP1
     1  MADMQNLVER LERAVGRLEA VSHTSDMHRG YADSPSKAGA APYVQAFDSL LAGPVAEYLK
    61  ISKEIGGDVQ KHAEMVHTGL KLERALLVTA SQCQQPAENK LSDLLAPISE QIKEVITFRE
   121  KNRGSKLFNH LSAVSESIQA LGWVAMAPKP GPYVKEMNDA AMFYTNRVLK EYKDVDKKHV
   181  DWVKAYLSIW TELQAYIKEF HTTGLAWSKT GPVAKELSGL PSGPSAGSCP PPPPPCPPPP
   241  PVSTISCSYE SASRSSLFAQ INQGESITHA LKHVSDDMKT HKNPALKAQS GPVRSGPKPF
   301  SAPKPQTSPS PKRATKKEPA VLELEGKKWR VENQENVSNL VIEDTELKQV AYIYKCVNTT
   361  LQIKGKINSI TVDNCKKLGL VFDDVVGIVE IINSKDVKVQ VMGKVPTISI NKTDGCHAYL
   421  SKNSLDCEIV SAKSSEMNVL IPTEGGDFNE FPVPEQFKTL WNGQKLVTTV TEIAG

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAP1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
306 nTPM

Expression across tissuesHPA

Tissue

  • tonsil: 306 nTPM
  • bone marrow: 298 nTPM
  • blood vessel: 280 nTPM
  • appendix: 260 nTPM
  • lymph node: 249 nTPM
  • smooth muscle: 221 nTPM

Single-cell type

  • neutrophils: 1,954 nCPM
  • neutrophil progenitors: 1,262 nCPM
  • platelets: 1,017 nCPM
  • megakaryocytes: 933 nCPM
  • esophageal apical cells: 697 nCPM
  • late spermatids: 650 nCPM

Immune cell

  • eosinophil: 2,600 nTPM
  • total PBMC: 1,839 nTPM
  • neutrophil: 1,567 nTPM
  • non-classical monocyte: 1,410 nTPM
  • basophil: 1,379 nTPM
  • intermediate monocyte: 1,099 nTPM

Brain region

  • white matter: 148 nTPM
  • medulla oblongata: 130 nTPM
  • thalamus: 117 nTPM
  • basal ganglia: 113 nTPM
  • spinal cord: 111 nTPM
  • pons: 107 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.55
gnomAD pLI
0.02
gnomAD missense Z
1.27
DepMap mean gene effect
-0.35
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CAP1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAP1 as an antibody target. Whether an autoantibody or antibody against CAP1 could matter depends on whether native CAP1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAP1 is annotated at the cell surface, where native CAP1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CAP1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CAP1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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