Seroatlas · Human Serome Atlas

CAMTA2

Calmodulin-binding transcription activator 2

Also known as: CMTA2_HUMAN, KIAA0909

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O94983
Gene: CAMTA2
Ensembl: ENSG00000108509
Chromosome: 17
Canonical length: 1202 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Vesicles,Actin filaments,Mitochondria,Cytosol

OverviewNCBI Gene

The protein encoded by this gene is a member of the calmodulin-binding transcription activator protein family. Members of this family share a common domain structure that consists of a transcription activation domain, a DNA-binding domain, and a calmodulin-binding domain. The encoded protein may be a transcriptional coactivator of genes involved in cardiac growth. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jan 2010]

Canonical amino-acid sequenceUniProt

1202 residues, UniProt reviewed canonical sequence.

>O94983|CAMTA2
     1  MNTKDTTEVA ENSHHLKIFL PKKLLECLPR CPLLPPERLR WNTNEEIASY LITFEKHDEW
    61  LSCAPKTRPQ NGSIILYNRK KVKYRKDGYL WKKRKDGKTT REDHMKLKVQ GMECLYGCYV
   121  HSSIVPTFHR RCYWLLQNPD IVLVHYLNVP ALEDCGKGCS PIFCSISSDR REWLKWSREE
   181  LLGQLKPMFH GIKWSCGNGT EEFSVEHLVQ QILDTHPTKP APRTHACLCS GGLGSGSLTH
   241  KCSSTKHRII SPKVEPRALT LTSIPHAHPP EPPPLIAPLP PELPKAHTSP SSSSSSSSSG
   301  FAEPLEIRPS PPTSRGGSSR GGTAILLLTG LEQRAGGLTP TRHLAPQADP RPSMSLAVVV
   361  GTEPSAPPAP PSPAFDPDRF LNSPQRGQTY GGGQGVSPDF PEAEAAHTPC SALEPAAALE
   421  PQAAARGPPP QSVAGGRRGN CFFIQDDDSG EELKGHGAAP PIPSPPPSPP PSPAPLEPSS
   481  RVGRGEALFG GPVGASELEP FSLSSFPDLM GELISDEAPS IPAPTPQLSP ALSTITDFSP
   541  EWSYPEGGVK VLITGPWTEA AEHYSCVFDH IAVPASLVQP GVLRCYCPAH EVGLVSLQVA
   601  GREGPLSASV LFEYRARRFL SLPSTQLDWL SLDDNQFRMS ILERLEQMEK RMAEIAAAGQ
   661  VPCQGPDAPP VQDEGQGPGF EARVVVLVES MIPRSTWKGP ERLAHGSPFR GMSLLHLAAA
   721  QGYARLIETL SQWRSVETGS LDLEQEVDPL NVDHFSCTPL MWACALGHLE AAVLLFRWNR
   781  QALSIPDSLG RLPLSVAHSR GHVRLARCLE ELQRQEPSVE PPFALSPPSS SPDTGLSSVS
   841  SPSELSDGTF SVTSAYSSAP DGSPPPAPLP ASEMTMEDMA PGQLSSGVPE APLLLMDYEA
   901  TNSKGPLSSL PALPPASDDG AAPEDADSPQ AVDVIPVDMI SLAKQIIEAT PERIKREDFV
   961  GLPEAGASMR ERTGAVGLSE TMSWLASYLE NVDHFPSSTP PSELPFERGR LAVPSAPSWA
  1021  EFLSASTSGK MESDFALLTL SDHEQRELYE AARVIQTAFR KYKGRRLKEQ QEVAAAVIQR
  1081  CYRKYKQLTW IALKFALYKK MTQAAILIQS KFRSYYEQKR FQQSRRAAVL IQQHYRSYRR
  1141  RPGPPHRTSA TLPARNKGSF LTKKQDQAAR KIMRFLRRCR HRMRELKQNQ ELEGLPQPGL
  1201  AT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CAMTA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.52
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

cerebellum: 66 nTPM
cerebral cortex: 50 nTPM
hippocampal formation: 37 nTPM
skeletal muscle: 36 nTPM
amygdala: 28 nTPM
tongue: 26 nTPM

Single-cell type

late spermatids: 85 nCPM
tuft cells: 58 nCPM
neutrophils: 50 nCPM
early spermatids: 43 nCPM
myonuclei: 41 nCPM
alveolar cells type 1: 34 nCPM

Immune cell

non-classical monocyte: 5 nTPM
neutrophil: 3.1 nTPM
intermediate monocyte: 1.6 nTPM
total PBMC: 1.4 nTPM
gdT-cell: 1.3 nTPM
classical monocyte: 1.2 nTPM

Brain region

cerebral cortex: 135 nTPM
hippocampal formation: 110 nTPM
white matter: 95 nTPM
amygdala: 82 nTPM
pons: 80 nTPM
basal ganglia: 77 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.26
gnomAD pLI: 1
gnomAD missense Z: 1.55
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CAMTA2 as an antibody target. Whether an autoantibody or antibody against CAMTA2 could matter depends on whether native CAMTA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CAMTA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CAMTA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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