Seroatlas · Human Serome Atlas

CACNG7

Voltage-dependent calcium channel gamma-7 subunit

Also known as: CCG7_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P62955
Gene
CACNG7
Ensembl
ENSG00000105605
Chromosome
19
Canonical length
275 aa
Protein class
FDA approved drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>P62955|CACNG7
     1  MSHCSSRALT LLSSVFGACG LLLVGIAVST DYWLYMEEGT VLPQNQTTEV KMALHAGLWR
    61  VCFFAGREKG RCVASEYFLE PEINLVTENT ENILKTVRTA TPFPMVSLFL VFTAFVISNI
   121  GHIRPQRTIL AFVSGIFFIL SGLSLVVGLV LYISSINDEV MNRPSSSEQY FHYRYGWSFA
   181  FAASSFLLKE GAGVMSVYLF TKRYAEEEMY RPHPAFYRPR LSDCSDYSGQ FLQPEAWRRG
   241  RSPSDISSDV SIQMTQNYPP AIKYPDHLHI STSPC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CACNG7 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.41
Highest tissue expression
79 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 79 nTPM
  • amygdala: 64 nTPM
  • cerebellum: 64 nTPM
  • hippocampal formation: 60 nTPM
  • midbrain: 44 nTPM
  • basal ganglia: 42 nTPM

Single-cell type

  • retinal horizontal cells: 441 nCPM
  • retinal amacrine cells: 69 nCPM
  • oligodendrocyte progenitor cells: 59 nCPM
  • retinal ganglion cells: 54 nCPM
  • brain inhibitory neurons: 49 nCPM
  • brain excitatory neurons: 45 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • cerebral cortex: 125 nTPM
  • thalamus: 115 nTPM
  • white matter: 102 nTPM
  • amygdala: 102 nTPM
  • midbrain: 96 nTPM
  • hippocampal formation: 95 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about CACNG7.

Disease | GeneticClinVar

1 pathogenic / likely-pathogenic of 36 ClinVar records.

Conditions with pathogenic or likely-pathogenic variants.

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.41
gnomAD pLI
0.89
gnomAD missense Z
1.65
DepMap mean gene effect
0.25
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CACNG7 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CACNG7 as an antibody target. Whether an autoantibody or antibody against CACNG7 could matter depends on whether native CACNG7 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CACNG7 is annotated at the cell surface, where native CACNG7 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CACNG7 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CACNG7. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

© 2026 · Seroatlas, Discover Oregon LLC · Terms of use

Loading the interactive Seroatlas protein explorer...