Seroatlas · Human Serome Atlas

CACNG6

Voltage-dependent calcium channel gamma-6 subunit

Also known as: CCG6_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9BXT2
Gene
CACNG6
Ensembl
ENSG00000130433
Chromosome
19
Canonical length
260 aa
Protein class
FDA approved drug targets, Predicted membrane proteins, Transporters
Subcellular location
Nucleoli fibrillar center,Cytosol

OverviewNCBI Gene

Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is an integral membrane protein that is thought to stabilize the calcium channel in an inactive (closed) state. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). Alternative splicing results in multiple transcript variants. Variants in this gene have been associated with aspirin-intolerant asthma. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

260 residues, UniProt reviewed canonical sequence.

>Q9BXT2|CACNG6
     1  MMWSNFFLQE ENRRRGAAGR RRAHGQGRSG LTPEREGKVK LALLLAAVGA TLAVLSVGTE
    61  FWVELNTYKA NGSAVCEAAH LGLWKACTKR LWQADVPVDR DTCGPAELPG EANCTYFKFF
   121  TTGENARIFQ RTTKKEVNLA AAVIAVLGLA VMALGCLCII MVLSKGAEFL LRVGAVCFGL
   181  SGLLLLVSLE VFRHSVRALL QRVSPEPPPA PRLTYEYSWS LGCGVGAGLI LLLGAGCFLL
   241  LTLPSWPWGS LCPKRGHRAT

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CACNG6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
85 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 85 nTPM
  • tongue: 28 nTPM
  • fallopian tube: 8.2 nTPM
  • parathyroid gland: 2.7 nTPM
  • lung: 2.2 nTPM
  • testis: 2.2 nTPM

Single-cell type

  • myonuclei: 102 nCPM
  • respiratory ciliated cells: 46 nCPM
  • thymic myoid cells: 29 nCPM
  • fallopian tube ciliated cells: 15 nCPM
  • ependymal cells: 11 nCPM
  • endometrial ciliated cells: 8.1 nCPM

Immune cell

  • basophil: 13 nTPM
  • eosinophil: 8 nTPM
  • classical monocyte: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • midbrain: 4 nTPM
  • spinal cord: 2.1 nTPM
  • medulla oblongata: 2 nTPM
  • cerebral cortex: 1.8 nTPM
  • hippocampal formation: 1.1 nTPM
  • hypothalamus: 1.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.69
gnomAD pLI
0
gnomAD missense Z
0.32
DepMap mean gene effect
-0.08
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CACNG6 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CACNG6 as an antibody target. Whether an autoantibody or antibody against CACNG6 could matter depends on whether native CACNG6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CACNG6 is annotated at the cell surface, where native CACNG6 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CACNG6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CACNG6. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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