Seroatlas · Human Serome Atlas

CACNG5

Voltage-dependent calcium channel gamma-5 subunit

Also known as: CCG5_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UF02
Gene
CACNG5
Ensembl
ENSG00000075429
Chromosome
17
Canonical length
275 aa
Protein class
FDA approved drug targets, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a type II transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type I TARP and a calcium channel gamma subunit. This gene is a susceptibility locus for schizophrenia and bipolar disorder. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

275 residues, UniProt reviewed canonical sequence.

>Q9UF02|CACNG5
     1  MSACGRKALT LLSSVFAVCG LGLLGIAVST DYWLYLEEGV IVPQNQSTEI KMSLHSGLWR
    61  VCFLAGEERG RCFTIEYVMP MNTQLTSEST VNVLKMIRSA TPFPLVSLFF MFIGFILNNI
   121  GHIRPHRTIL AFVSGIFFIL SGLSLVVGLV LYISSINDEM LNRTKDAETY FNYKYGWSFA
   181  FAAISFLLTE SAGVMSVYLF MKRYTAEDMY RPHPGFYRPR LSNCSDYSGQ FLHPDAWVRG
   241  RSPSDISSEA SLQMNSNYPA LLKCPDYDQM SSSPC

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CACNG5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.4
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • retina: 15 nTPM
  • cerebral cortex: 3.1 nTPM
  • basal ganglia: 2.8 nTPM
  • amygdala: 2.5 nTPM
  • hippocampal formation: 1.9 nTPM
  • hypothalamus: 1.7 nTPM

Single-cell type

  • retinal horizontal cells: 170 nCPM
  • retinal amacrine cells: 140 nCPM
  • retinal ganglion cells: 104 nCPM
  • oligodendrocyte progenitor cells: 54 nCPM
  • bergmann glia: 22 nCPM
  • retinal bipolar cells: 19 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • thalamus: 25 nTPM
  • midbrain: 14 nTPM
  • spinal cord: 14 nTPM
  • cerebral cortex: 14 nTPM
  • amygdala: 11 nTPM
  • medulla oblongata: 8.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.03
gnomAD pLI
0.01
gnomAD missense Z
0.24
DepMap mean gene effect
-0.06
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 2% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CACNG5 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CACNG5 as an antibody target. Whether an autoantibody or antibody against CACNG5 could matter depends on whether native CACNG5 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CACNG5 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label CACNG5 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CACNG5. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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