Seroatlas · Human Serome Atlas

CACNG4

Voltage-dependent calcium channel gamma-4 subunit

Also known as: CCG4_HUMAN, MGC11138, MGC24983

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9UBN1
Gene
CACNG4
Ensembl
ENSG00000075461
Chromosome
17
Canonical length
327 aa
Protein class
FDA approved drug targets, Predicted membrane proteins, Transporters
Subcellular location
Vesicles

OverviewNCBI Gene

The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members, a type II TARP and a calcium channel gamma subunit. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

327 residues, UniProt reviewed canonical sequence.

>Q9UBN1|CACNG4
     1  MVRCDRGLQM LLTTAGAFAA FSLMAIAIGT DYWLYSSAHI CNGTNLTMDD GPPPRRARGD
    61  LTHSGLWRVC CIEGIYKGHC FRINHFPEDN DYDHDSSEYL LRIVRASSVF PILSTILLLL
   121  GGLCIGAGRI YSRKNNIVLS AGILFVAAGL SNIIGIIVYI SSNTGDPSDK RDEDKKNHYN
   181  YGWSFYFGAL SFIVAETVGV LAVNIYIEKN KELRFKTKRE FLKASSSSPY ARMPSYRYRR
   241  RRSRSSSRST EASPSRDVSP MGLKITGAIP MGELSMYTLS REPLKVTTAA SYSPDQEASF
   301  LQVHDFFQQD LKEGFHVSML NRRTTPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CACNG4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.48
Highest tissue expression
58 nTPM

Expression across tissuesHPA

Tissue

  • basal ganglia: 58 nTPM
  • amygdala: 35 nTPM
  • hypothalamus: 29 nTPM
  • cerebral cortex: 24 nTPM
  • hippocampal formation: 24 nTPM
  • midbrain: 17 nTPM

Single-cell type

  • oligodendrocyte progenitor cells: 284 nCPM
  • alveolar cells type 1: 104 nCPM
  • bergmann glia: 89 nCPM
  • brain inhibitory neurons: 74 nCPM
  • adrenal medulla cells: 43 nCPM
  • respiratory ciliated cells: 39 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 68 nTPM
  • thalamus: 58 nTPM
  • amygdala: 51 nTPM
  • hypothalamus: 33 nTPM
  • midbrain: 31 nTPM
  • cerebral cortex: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.83
gnomAD pLI
0.02
gnomAD missense Z
1.82
DepMap mean gene effect
0.01
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CACNG4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CACNG4 as an antibody target. Whether an autoantibody or antibody against CACNG4 could matter depends on whether native CACNG4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CACNG4 is annotated at the cell surface, where native CACNG4 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CACNG4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CACNG4. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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