Seroatlas · Human Serome Atlas

CACNG3

Voltage-dependent calcium channel gamma-3 subunit

Also known as: CCG3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: O60359
Gene: CACNG3
Ensembl: ENSG00000006116
Chromosome: 16
Canonical length: 315 aa
Protein class: FDA approved drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

The protein encoded by this gene is a type I transmembrane AMPA receptor regulatory protein (TARP). TARPs regulate both trafficking and channel gating of the AMPA receptors. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family. This gene is a susceptibility locus for childhood absence epilepsy. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

315 residues, UniProt reviewed canonical sequence.

>O60359|CACNG3
     1  MRMCDRGIQM LITTVGAFAA FSLMTIAVGT DYWLYSRGVC RTKSTSDNET SRKNEEVMTH
    61  SGLWRTCCLE GAFRGVCKKI DHFPEDADYE QDTAEYLLRA VRASSVFPIL SVTLLFFGGL
   121  CVAASEFHRS RHNVILSAGI FFVSAGLSNI IGIIVYISAN AGDPGQRDSK KSYSYGWSFY
   181  FGAFSFIIAE IVGVVAVHIY IEKHQQLRAK SHSEFLKKST FARLPPYRYR FRRRSSSRST
   241  EPRSRDLSPI SKGFHTIPST DISMFTLSRD PSKITMGTLL NSDRDHAFLQ FHNSTPKEFK
   301  ESLHNNPANR RTTPV

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CACNG3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 4
Mean surface accessibility (rSASA): 0.47
Highest tissue expression: 67 nTPM

Expression across tissuesHPA

Tissue

cerebral cortex: 67 nTPM
hippocampal formation: 45 nTPM
basal ganglia: 43 nTPM
amygdala: 42 nTPM
retina: 16 nTPM
hypothalamus: 8.5 nTPM

Single-cell type

retinal horizontal cells: 771 nCPM
retinal amacrine cells: 164 nCPM
brain excitatory neurons: 142 nCPM
brain inhibitory neurons: 127 nCPM
adrenal medulla cells: 53 nCPM
other brain neurons: 43 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

cerebral cortex: 82 nTPM
hippocampal formation: 67 nTPM
basal ganglia: 60 nTPM
white matter: 55 nTPM
amygdala: 30 nTPM
midbrain: 30 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.2
gnomAD pLI: 0.99
gnomAD missense Z: 2.64
DepMap mean gene effect: -0.07
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of CACNG3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CACNG3 as an antibody target. Whether an autoantibody or antibody against CACNG3 could matter depends on whether native CACNG3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CACNG3 is annotated at the cell surface, where native CACNG3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CACNG3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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