Seroatlas · Human Serome Atlas

CACNG1

Voltage-dependent calcium channel gamma-1 subunit

Also known as: CACNLG, CCG1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q06432
Gene
CACNG1
Ensembl
ENSG00000108878
Chromosome
17
Canonical length
222 aa
Protein class
FDA approved drug targets, Predicted membrane proteins, Transporters

OverviewNCBI Gene

Voltage-dependent calcium channels are composed of five subunits. The protein encoded by this gene represents one of these subunits, gamma, and is one of two known gamma subunit proteins. This particular gamma subunit is part of skeletal muscle 1,4-dihydropyridine-sensitive calcium channels and is an integral membrane protein that plays a role in excitation-contraction coupling. This gene is part of a functionally diverse eight-member protein subfamily of the PMP-22/EMP/MP20 family and is located in a cluster with two family members that function as transmembrane AMPA receptor regulatory proteins (TARPs). [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

222 residues, UniProt reviewed canonical sequence.

>Q06432|CACNG1
     1  MSQTKMLKVR VTLFCILAGI VLAMTAVVTD HWAVLSPHME HHNTTCEAAH FGLWRICTKR
    61  IPMDDSKTCG PITLPGEKNC SYFRHFNPGE SSEIFEFTTQ KEYSISAAAI AIFSLGFIIL
   121  GSLCVLLSLG KKRDYLLRPA SMFYAFAGLC ILVSVEVMRQ SVKRMIDSED TVWIEYYYSW
   181  SFACACAAFI LLFLGGLALL LFSLPRMPRN PWESCMDAEP EH

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against CACNG1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
4
Mean surface accessibility (rSASA)
0.34
Highest tissue expression
312 nTPM

Expression across tissuesHPA

Tissue

  • skeletal muscle: 312 nTPM
  • tongue: 114 nTPM
  • esophagus: 3.8 nTPM
  • salivary gland: 3 nTPM
  • basal ganglia: 2.2 nTPM
  • adrenal gland: 1.6 nTPM

Single-cell type

  • myonuclei: 127 nCPM
  • thymic myoid cells: 118 nCPM
  • myosatellite cells: 4.7 nCPM
  • adipocytes: 3.1 nCPM
  • fibro-adipogenic progenitors: 2.4 nCPM
  • cardiomyocytes: 2.3 nCPM

Immune cell

  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM
  • intermediate monocyte: 0 nTPM
  • MAIT T-cell: 0 nTPM

Brain region

  • basal ganglia: 1.7 nTPM
  • amygdala: 1.3 nTPM
  • thalamus: 1 nTPM
  • cerebral cortex: 0.8 nTPM
  • hippocampal formation: 0.6 nTPM
  • hypothalamus: 0.6 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.82
gnomAD pLI
0
gnomAD missense Z
0.32
DepMap mean gene effect
-0.09
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads CACNG1 as an antibody target. Whether an autoantibody or antibody against CACNG1 could matter depends on whether native CACNG1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

CACNG1 is annotated at the cell surface, where native CACNG1 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label CACNG1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/CACNG1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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