Seroatlas · Human Serome Atlas

C6orf89

Bombesin receptor-activated protein C6orf89

Also known as: BRAP, CF089_HUMAN, FLJ25357

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q6UWU4
Gene: C6orf89
Ensembl: ENSG00000198663
Chromosome: 6
Canonical length: 347 aa
Protein class: Predicted intracellular proteins, Predicted membrane proteins
Quaternary structure: Homodimer

OverviewNCBI Gene

Involved in several processes, including chromatin remodeling; epithelial cell proliferation; and wound healing. Located in several cellular components, including Golgi membrane; midbody; and nucleolus. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

347 residues, UniProt reviewed canonical sequence.

>Q6UWU4|C6orf89
     1  MDLAANEISI YDKLSETVDL VRQTGHQCGM SEKAIEKFIR QLLEKNEPQR PPPQYPLLIV
    61  VYKVLATLGL ILLTAYFVIQ PFSPLAPEPV LSGAHTWRSL IHHIRLMSLP IAKKYMSENK
   121  GVPLHGGDED RPFPDFDPWW TNDCEQNESE PIPANCTGCA QKHLKVMLLE DAPRKFERLH
   181  PLVIKTGKPL LEEEIQHFLC QYPEATEGFS EGFFAKWWRC FPERWFPFPY PWRRPLNRSQ
   241  MLRELFPVFT HLPFPKDASL NKCSFLHPEP VVGSKMHKMP DLFIIGSGEA MLQLIPPFQC
   301  RRHCQSVAMP IEPGDIGYVD TTHWKVYVIA RGVQPLVICD GTAFSEL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C6orf89 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Other membrane
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.43
Highest tissue expression: 55 nTPM

Expression across tissuesHPA

Tissue

thyroid gland: 55 nTPM
parathyroid gland: 51 nTPM
epididymis: 47 nTPM
heart muscle: 47 nTPM
seminal vesicle: 45 nTPM
testis: 44 nTPM

Single-cell type

late spermatids: 1,014 nCPM
early spermatids: 434 nCPM
corticotrophs: 168 nCPM
epididymal principal cells: 164 nCPM
esophageal apical cells: 154 nCPM
late primary spermatocytes: 116 nCPM

Immune cell

basophil: 28 nTPM
neutrophil: 27 nTPM
non-classical monocyte: 23 nTPM
eosinophil: 21 nTPM
gdT-cell: 18 nTPM
MAIT T-cell: 18 nTPM

Brain region

white matter: 79 nTPM
hypothalamus: 72 nTPM
spinal cord: 70 nTPM
midbrain: 69 nTPM
medulla oblongata: 69 nTPM
pons: 68 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.09
gnomAD pLI: 0
gnomAD missense Z: 0.5
DepMap mean gene effect: -0.18
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

Bombesin receptor-activated protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of C6orf89 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

BRS3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C6orf89 as an antibody target. Whether an autoantibody or antibody against C6orf89 could matter depends on whether native C6orf89 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C6orf89 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C6orf89 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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