Seroatlas · Human Serome Atlas

BRS3

Bombesin receptor subtype-3

Also known as: BB3, BB3R, BBR3, BRS3_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
P32247
Gene
BRS3
Ensembl
ENSG00000102239
Chromosome
X
Canonical length
399 aa
Protein class
G-protein coupled receptors, Plasma proteins, Predicted membrane proteins

OverviewNCBI Gene

The protein encoded by this gene is a G protein-coupled membrane receptor that binds bombesin-like peptides. This binding results in activation of a phosphatidylinositol-calcium second messenger system, with physiological effects including regulation of metabolic rate, glucose metabolism, and hypertension. [provided by RefSeq, Sep 2011]

Canonical amino-acid sequenceUniProt

399 residues, UniProt reviewed canonical sequence.

>P32247|BRS3
     1  MAQRQPHSPN QTLISITNDT ESSSSVVSND NTNKGWSGDN SPGIEALCAI YITYAVIISV
    61  GILGNAILIK VFFKTKSMQT VPNIFITSLA FGDLLLLLTC VPVDATHYLA EGWLFGRIGC
   121  KVLSFIRLTS VGVSVFTLTI LSADRYKAVV KPLERQPSNA ILKTCVKAGC VWIVSMIFAL
   181  PEAIFSNVYT FRDPNKNMTF ESCTSYPVSK KLLQEIHSLL CFLVFYIIPL SIISVYYSLI
   241  ARTLYKSTLN IPTEEQSHAR KQIESRKRIA RTVLVLVALF ALCWLPNHLL YLYHSFTSQT
   301  YVDPSAMHFI FTIFSRVLAF SNSCVNPFAL YWLSKSFQKH FKAQLFCCKA ERPEPPVADT
   361  SLTTLAVMGT VPGTGSIQMS EISVTSFTGC SVKQAEDRF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRS3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Cell surface
Secreted
No
Transmembrane segments
7
Mean surface accessibility (rSASA)
0.38
Highest tissue expression
24 nTPM

Expression across tissuesHPA

Tissue

  • epididymis: 24 nTPM
  • basal ganglia: 1.1 nTPM
  • fallopian tube: 0.9 nTPM
  • hypothalamus: 0.9 nTPM
  • ovary: 0.9 nTPM
  • testis: 0.3 nTPM

Single-cell type

  • epididymal principal cells: 134 nCPM
  • oocytes: 14 nCPM
  • undifferentiated spermatogonia: 2.8 nCPM
  • epididymal basal cells: 1.5 nCPM
  • other brain neurons: 1.5 nCPM
  • pancreatic islet cells: 1.3 nCPM

Immune cell

  • naive B-cell: 0.1 nTPM
  • naive CD8 T-cell: 0.1 nTPM
  • basophil: 0 nTPM
  • classical monocyte: 0 nTPM
  • eosinophil: 0 nTPM
  • gdT-cell: 0 nTPM

Brain region

  • hypothalamus: 1.6 nTPM
  • basal ganglia: 0.8 nTPM
  • hippocampal formation: 0.5 nTPM
  • cerebral cortex: 0.4 nTPM
  • amygdala: 0.1 nTPM
  • midbrain: 0.1 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.32
gnomAD pLI
0.95
gnomAD missense Z
0.94
DepMap mean gene effect
0.18
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 3% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BRS3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BRS3 as an antibody target. Whether an autoantibody or antibody against BRS3 could matter depends on whether native BRS3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BRS3 is annotated at the cell surface, where native BRS3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label BRS3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BRS3. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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