Seroatlas · Human Serome Atlas

C5orf63

Glutaredoxin-like protein C5orf63

Also known as: FLJ44606, YD286_HUMAN, YDR286C

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
A6NC05
Gene
C5orf63
Ensembl
ENSG00000164241
Chromosome
5
Canonical length
138 aa
Protein class
Predicted intracellular proteins
Subcellular location
Mitochondria

OverviewNCBI Gene

Located in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

138 residues, UniProt reviewed canonical sequence.

>A6NC05|C5orf63
     1  MLWFQGNSMQ LARSSFGLFL RNCSASKTTL PVLTLFTKDP CPLCDEAKEV LKPYENRQPY
    61  KDQKLPGTRR RRSPSSPSHP HMASQSGKRY NLTLNQVLSF DYDMGLDAPK TISSDCGAFY
   121  CLRMFKSPDM TCCFYPKQ

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C5orf63 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Unknown
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.53
Highest tissue expression
12 nTPM

Expression across tissuesHPA

Tissue

  • retina: 12 nTPM
  • testis: 12 nTPM
  • rectum: 11 nTPM
  • thyroid gland: 8.3 nTPM
  • tonsil: 7.7 nTPM
  • lymph node: 7.6 nTPM

Single-cell type

  • tuft cells: 69 nCPM
  • sertoli cells: 58 nCPM
  • late primary spermatocytes: 54 nCPM
  • early primary spermatocytes: 52 nCPM
  • ependymal cells: 39 nCPM
  • lactotrophs: 36 nCPM

Immune cell

  • naive B-cell: 11 nTPM
  • memory B-cell: 11 nTPM
  • NK-cell: 10 nTPM
  • plasmacytoid DC: 9.4 nTPM
  • naive CD4 T-cell: 7.9 nTPM
  • T-reg: 7.6 nTPM

Brain region

  • medulla oblongata: 5.9 nTPM
  • hypothalamus: 5.6 nTPM
  • spinal cord: 5.6 nTPM
  • thalamus: 5.3 nTPM
  • midbrain: 5 nTPM
  • white matter: 4.8 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.91
gnomAD pLI
0
gnomAD missense Z
0.56
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C5orf63 as an antibody target. Whether an autoantibody or antibody against C5orf63 could matter depends on whether native C5orf63 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C5orf63 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C5orf63 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/C5orf63. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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