Seroatlas · Human Serome Atlas

C4orf46

Renal cancer differentiation gene 1 protein

Also known as: CD046_HUMAN, LOC201725, RCDG1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q504U0
Gene: C4orf46
Ensembl: ENSG00000205208
Chromosome: 4
Canonical length: 113 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

This gene encodes a small, conserved protein of unknown function that is expressed in a variety of tissues. There are pseudogenes for this gene on chromosomes 6, 8, 16, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2013]

Canonical amino-acid sequenceUniProt

113 residues, UniProt reviewed canonical sequence.

>Q504U0|C4orf46
     1  MADPEELQVS SPPPPPPSSP SSSDASAASS PGGPVSLGWP VPSRSSGPTV DQLEEVELQI
    61  GDAAFSLTKL LEATSAVSAQ VEELAFKCTE NARFLKTWRD LLKEGYDSLK PDD

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against C4orf46 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.6
Highest tissue expression: 14 nTPM

Expression across tissuesHPA

Tissue

bone marrow: 14 nTPM
testis: 12 nTPM
thymus: 9.5 nTPM
retina: 8.7 nTPM
lymph node: 5.6 nTPM
tongue: 5.6 nTPM

Single-cell type

late primary spermatocytes: 60 nCPM
early primary spermatocytes: 44 nCPM
rod photoreceptor cells: 34 nCPM
melanocytes: 31 nCPM
monocyte progenitors: 29 nCPM
endometrial luminal cells: 24 nCPM

Immune cell

NK-cell: 3.4 nTPM
basophil: 2.4 nTPM
naive CD8 T-cell: 2.3 nTPM
non-classical monocyte: 2.2 nTPM
myeloid DC: 2.1 nTPM
naive CD4 T-cell: 2.1 nTPM

Brain region

white matter: 4.9 nTPM
cerebellum: 3.9 nTPM
basal ganglia: 3.8 nTPM
medulla oblongata: 3.7 nTPM
midbrain: 3.5 nTPM
cerebral cortex: 3.3 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.76
gnomAD pLI: 0.04
gnomAD missense Z: -0.24
DepMap mean gene effect: -0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Cellular components

cytosol

Protein domainsUniProt · Pfam · InterPro

Renal cancer differentiation gene 1 protein
Renal cancer differentiation gene 1 protein

KeywordsUniProt

Cytoplasm

InteractionsUniProt · HPA

Protein binding partners of C4orf46 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads C4orf46 as an antibody target. Whether an autoantibody or antibody against C4orf46 could matter depends on whether native C4orf46 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

C4orf46 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label C4orf46 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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