C1QTNF6
Complement C1q tumor necrosis factor-related protein 6
Also known as: C1QT6_HUMAN, CTRP6, ZACRP6
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q9BXI9
- Gene
- C1QTNF6
- Ensembl
- ENSG00000133466
- Chromosome
- 22
- Canonical length
- 278 aa
- Protein class
- Predicted intracellular proteins, Predicted secreted proteins
- Subcellular location
- Nucleoplasm
- Secretome location
- Secreted to blood
OverviewNCBI Gene
Enables identical protein binding activity. Predicted to be located in extracellular region and membrane. Predicted to be part of collagen trimer. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Jul 2025]
Canonical amino-acid sequenceUniProt
278 residues, UniProt reviewed canonical sequence.
>Q9BXI9|C1QTNF6
1 MQWLRVRESP GEATGHRVTM GTAALGPVWA ALLLFLLMCE IPMVELTFDR AVASGCQRCC
61 DSEDPLDPAH VSSASSSGRP HALPEIRPYI NITILKGDKG DPGPMGLPGY MGREGPQGEP
121 GPQGSKGDKG EMGSPGAPCQ KRFFAFSVGR KTALHSGEDF QTLLFERVFV NLDGCFDMAT
181 GQFAAPLRGI YFFSLNVHSW NYKETYVHIM HNQKEAVILY AQPSERSIMQ SQSVMLDLAY
241 GDRVWVRLFK RQRENAIYSN DFDTYITFSG HLIKAEDDLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C1QTNF6 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Secreted
- Secreted
- Yes
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.5
- Highest tissue expression
- 30 nTPM
Expression across tissuesHPA
Tissue
- endometrium: 30 nTPM
- placenta: 28 nTPM
- liver: 14 nTPM
- cervix: 11 nTPM
- gallbladder: 8.2 nTPM
- smooth muscle: 7.6 nTPM
Single-cell type
- extravillous trophoblasts: 599 nCPM
- migrating cytotrophoblasts: 56 nCPM
- syncytiotrophoblasts: 33 nCPM
- breast hormone-responsive cells: 31 nCPM
- decidual stromal cells: 30 nCPM
- endometrial stromal cells: 27 nCPM
Immune cell
- NK-cell: 1.5 nTPM
- T-reg: 1.4 nTPM
- naive CD4 T-cell: 0.9 nTPM
- naive B-cell: 0.7 nTPM
- naive CD8 T-cell: 0.7 nTPM
- neutrophil: 0.6 nTPM
Brain region
- white matter: 7 nTPM
- medulla oblongata: 5.1 nTPM
- thalamus: 4.6 nTPM
- cerebral cortex: 4.5 nTPM
- pons: 4.4 nTPM
- hippocampal formation: 3.8 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.62
- gnomAD pLI
- 0
- gnomAD missense Z
- 0.51
- DepMap mean gene effect
- -0.03
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
OntologyGO
Molecular functions
Cellular components
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C1QTNF6 as an antibody target. Whether an autoantibody or antibody against C1QTNF6 could matter depends on whether native C1QTNF6 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C1QTNF6 is annotated as secreted, so native C1QTNF6 circulates and is directly accessible to antibodies. Secreted and cell-surface proteins are the autoantibody targets most likely to act like drugs, blocking or depleting the native protein.
Annotation status
The present source text does not explicitly label C1QTNF6 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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