C16orf87
UPF0547 protein C16orf87
Also known as: CP087_HUMAN
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q6PH81
- Gene
- C16orf87
- Ensembl
- ENSG00000155330
- Chromosome
- 16
- Canonical length
- 154 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Nuclear bodies
OverviewNCBI Gene
No narrative summary is available for C16orf87 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
154 residues, UniProt reviewed canonical sequence.
>Q6PH81|C16orf87
1 MSATRAKKVK MATKSCPECD QQVPVACKSC PCGYIFISRK LLNAKHSEKS PPSTENKHEA
61 KRRRTERVRR EKINSTVNKD LENRKRSRSN SHSDHIRRGR GRPKSASAKK HEEEREKQEK
121 EIDIYANLSD EKAFVFSVAL AEINRKIINQ RLILLocalizationUniProt · AlphaFold · HPA
Whether an antibody against C16orf87 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.62
- Highest tissue expression
- 17 nTPM
Expression across tissuesHPA
Tissue
- testis: 17 nTPM
- bone marrow: 11 nTPM
- skeletal muscle: 8.8 nTPM
- liver: 8.5 nTPM
- tongue: 7 nTPM
- lymph node: 5.7 nTPM
Single-cell type
- late primary spermatocytes: 194 nCPM
- early primary spermatocytes: 165 nCPM
- differentiating spermatogonia: 109 nCPM
- cytotrophoblasts: 87 nCPM
- oocytes: 74 nCPM
- migrating cytotrophoblasts: 72 nCPM
Immune cell
- T-reg: 14 nTPM
- memory B-cell: 12 nTPM
- myeloid DC: 9.7 nTPM
- intermediate monocyte: 8.8 nTPM
- non-classical monocyte: 8.3 nTPM
- eosinophil: 8.1 nTPM
Brain region
- basal ganglia: 11 nTPM
- cerebral cortex: 11 nTPM
- hippocampal formation: 9.6 nTPM
- white matter: 8.7 nTPM
- choroid plexus: 8.6 nTPM
- amygdala: 8.5 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 1.11
- gnomAD pLI
- 0
- gnomAD missense Z
- 1.44
- DepMap mean gene effect
- -0.04
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
- Uncharacterised domain UPF0547
- UPF0547 protein C16orf87-like
- Uncharacterised protein family UPF0547
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of C16orf87 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads C16orf87 as an antibody target. Whether an autoantibody or antibody against C16orf87 could matter depends on whether native C16orf87 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
C16orf87 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label C16orf87 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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