BTF3L4
Transcription factor BTF3 homolog 4
Also known as: BT3L4_HUMAN, MGC23908
Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene
Protein identityUniProt · HPA
- UniProt accession
- Q96K17
- Gene
- BTF3L4
- Ensembl
- ENSG00000134717
- Chromosome
- 1
- Canonical length
- 158 aa
- Protein class
- Predicted intracellular proteins
- Subcellular location
- Nucleoplasm,Cytosol
OverviewNCBI Gene
No narrative summary is available for BTF3L4 in this catalog release; identity and structured annotations are shown without generated factual claims.
Canonical amino-acid sequenceUniProt
158 residues, UniProt reviewed canonical sequence.
>Q96K17|BTF3L4
1 MNQEKLAKLQ AQVRIGGKGT ARRKKKVVHR TATADDKKLQ SSLKKLAVNN IAGIEEVNMI
61 KDDGTVIHFN NPKVQASLSA NTFAITGHAE AKPITEMLPG ILSQLGADSL TSLRKLAEQF
121 PRQVLDSKAP KPEDIDEEDD DVPDLVENFD EASKNEANLocalizationUniProt · AlphaFold · HPA
Whether an antibody against BTF3L4 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.
- Antibody reachability
- Unknown
- Secreted
- No
- Transmembrane segments
- 0
- Mean surface accessibility (rSASA)
- 0.53
- Highest tissue expression
- 65 nTPM
Expression across tissuesHPA
Tissue
- skeletal muscle: 65 nTPM
- ovary: 61 nTPM
- bone marrow: 58 nTPM
- tongue: 55 nTPM
- adrenal gland: 49 nTPM
- thymus: 46 nTPM
Single-cell type
- esophageal apical cells: 270 nCPM
- oocytes: 249 nCPM
- parietal cells: 212 nCPM
- esophageal suprabasal cells: 190 nCPM
- kupffer cells: 182 nCPM
- decidual stromal cells: 176 nCPM
Immune cell
- intermediate monocyte: 79 nTPM
- classical monocyte: 74 nTPM
- myeloid DC: 73 nTPM
- non-classical monocyte: 71 nTPM
- eosinophil: 71 nTPM
- basophil: 71 nTPM
Brain region
- white matter: 64 nTPM
- cerebral cortex: 55 nTPM
- hypothalamus: 52 nTPM
- pons: 48 nTPM
- medulla oblongata: 47 nTPM
- midbrain: 47 nTPM
Genetic constraint and essentialitygnomAD · DepMap
Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.
- gnomAD LOEUF (loss-of-function intolerance)
- 0.7
- gnomAD pLI
- 0.57
- gnomAD missense Z
- 1.86
- DepMap mean gene effect
- -0.43
- DepMap dependency class
- selective
Cancer expressionTCGA
Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).
Protein domainsUniProt · Pfam · InterPro
KeywordsUniProt
InteractionsUniProt · HPA
Protein binding partners of BTF3L4 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.
Antibody and autoantibody relevanceSeroatlas analysis
Seroatlas reads BTF3L4 as an antibody target. Whether an autoantibody or antibody against BTF3L4 could matter depends on whether native BTF3L4 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.
BTF3L4 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.
Annotation status
The present source text does not explicitly label BTF3L4 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.
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