BTC

Protein identityUniProt · HPA

UniProt accession

P35070

Gene

BTC

Ensembl

ENSG00000174808

Chromosome

4

Canonical length

178 aa

Protein class

Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Secretome location

Secreted to blood

OverviewNCBI Gene

This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients. [provided by RefSeq, Nov 2015]

Canonical amino-acid sequenceUniProt

178 residues, UniProt reviewed canonical sequence.

>P35070|BTC
     1  MDRAARCSGA SSLPLLLALA LGLVILHCVV ADGNSTRSPE TNGLLCGDPE ENCAATTTQS
    61  KRKGHFSRCP KQYKHYCIKG RCRFVVAEQT PSCVCDEGYI GARCERVDLF YLRGDRGQIL
   121  VICLIAVMVV FIILVIGVCT CCHPLRKRRK RKKKEEEMET LGKDITPINE DIEETNIA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BTC can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.52

Highest tissue expression

25 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1

gnomAD pLI

0.06

gnomAD missense Z

-0.13

DepMap mean gene effect

0.04

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• cell population proliferation
• epidermal growth factor receptor signaling pathway
• epithelial cell apoptotic process
• ERBB2-EGFR signaling pathway
• ERBB4-ERBB4 signaling pathway
• negative regulation of epithelial cell apoptotic process
• positive regulation of cell differentiation
• positive regulation of cell division
• positive regulation of cell population proliferation
• positive regulation of fibroblast proliferation
• positive regulation of mitotic nuclear division
• positive regulation of urine volume

Molecular functions

• epidermal growth factor receptor binding
• growth factor activity
• receptor ligand activity
• transmembrane receptor protein tyrosine kinase activator activity

Cellular components

• clathrin-coated endocytic vesicle membrane
• extracellular region
• extracellular space
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• EGF-like domain

KeywordsUniProt

• Cell membrane
• Disulfide bond
• EGF-like domain
• Glycoprotein
• Growth factor
• Membrane
• Mitogen
• Secreted
• Signal
• Transmembrane
• Transmembrane helix

InteractionsUniProt · HPA

Protein binding partners of BTC in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• EGFR
• ERBB4