Seroatlas · Human Serome Atlas

BRD2

Bromodomain-containing protein 2

Also known as: BRD2_HUMAN, BRD2-IT1, D6S113E, FSRG1, KIAA9001, NAT, RING3

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P25440
Gene: BRD2
Ensembl: ENSG00000204256
Chromosome: 6
Canonical length: 801 aa
Protein class: Predicted intracellular proteins
Subcellular location: Nucleoplasm,Nuclear speckles
Quaternary structure: Homodimer

OverviewNCBI Gene

This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]

Canonical amino-acid sequenceUniProt

801 residues, UniProt reviewed canonical sequence.

>P25440|BRD2
     1  MLQNVTPHNK LPGEGNAGLL GLGPEAAAPG KRIRKPSLLY EGFESPTMAS VPALQLTPAN
    61  PPPPEVSNPK KPGRVTNQLQ YLHKVVMKAL WKHQFAWPFR QPVDAVKLGL PDYHKIIKQP
   121  MDMGTIKRRL ENNYYWAASE CMQDFNTMFT NCYIYNKPTD DIVLMAQTLE KIFLQKVASM
   181  PQEEQELVVT IPKNSHKKGA KLAALQGSVT SAHQVPAVSS VSHTALYTPP PEIPTTVLNI
   241  PHPSVISSPL LKSLHSAGPP LLAVTAAPPA QPLAKKKGVK RKADTTTPTP TAILAPGSPA
   301  SPPGSLEPKA ARLPPMRRES GRPIKPPRKD LPDSQQQHQS SKKGKLSEQL KHCNGILKEL
   361  LSKKHAAYAW PFYKPVDASA LGLHDYHDII KHPMDLSTVK RKMENRDYRD AQEFAADVRL
   421  MFSNCYKYNP PDHDVVAMAR KLQDVFEFRY AKMPDEPLEP GPLPVSTAMP PGLAKSSSES
   481  SSEESSSESS SEEEEEEDEE DEEEEESESS DSEEERAHRL AELQEQLRAV HEQLAALSQG
   541  PISKPKRKRE KKEKKKKRKA EKHRGRAGAD EDDKGPRAPR PPQPKKSKKA SGSGGGSAAL
   601  GPSGFGPSGG SGTKLPKKAT KTAPPALPTG YDSEEEEESR PMSYDEKRQL SLDINKLPGE
   661  KLGRVVHIIQ AREPSLRDSN PEEIEIDFET LKPSTLRELE RYVLSCLRKK PRKPYTIKKP
   721  VGKTKEELAL EKKRELEKRL QDVSGQLNST KKPPKKANEK TESSSAQQVA VSRLSASSSS
   781  SDSSSSSSSS SSSDTSDSDS G

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BRD2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.56
Highest tissue expression: 66 nTPM

Expression across tissuesHPA

Tissue

pancreas: 66 nTPM
bone marrow: 63 nTPM
thyroid gland: 32 nTPM
testis: 31 nTPM
thymus: 25 nTPM
blood vessel: 25 nTPM

Single-cell type

epididymal principal cells: 269 nCPM
epididymal basal cells: 232 nCPM
early spermatids: 154 nCPM
epididymal clear cells: 110 nCPM
breast secretory cells: 109 nCPM
epididymal efferent duct absorptive cells: 101 nCPM

Immune cell

gdT-cell: 15 nTPM
T-reg: 13 nTPM
MAIT T-cell: 13 nTPM
total PBMC: 12 nTPM
eosinophil: 12 nTPM
myeloid DC: 11 nTPM

Brain region

cerebral cortex: 41 nTPM
cerebellum: 37 nTPM
white matter: 35 nTPM
hypothalamus: 34 nTPM
thalamus: 33 nTPM
hippocampal formation: 33 nTPM

DiseaseUniProt · ClinVar · IEDB · PubMed

Four sources answering four different questions about BRD2.

Disease | ImmuneIEDB

Conditions an epitope on BRD2 was assayed in.

narcolepsy B cell
multiple sclerosis B cell
peripheral nervous system disease B cell

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.22
gnomAD pLI: 1
gnomAD missense Z: 0.59
DepMap mean gene effect: -0.44
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 6% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BRD2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BRD2 as an antibody target. Whether an autoantibody or antibody against BRD2 could matter depends on whether native BRD2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BRD2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BRD2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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