Seroatlas · Human Serome Atlas

BOLA2

BolA-like protein 2

Also known as: BOLA2_HUMAN, BOLA2A, BOLA2B, My016

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9H3K6
Gene: BOLA2
Ensembl: ENSG00000183336
Chromosome: 16
Canonical length: 86 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

This gene is located within a region of a segmental duplication on chromosome 16 and is identical to BOLA2B (bolA family member 2B). The product of this gene belongs to a family of proteins that are widely conserved and may be involved in iron maturation. Related pseudogenes are found multiple different chromosomes. Alternative splicing results in multiple transcript variants. Transcripts initiating at this locus may extend into downstream SMG1 pseudogene 6 (SMG1P6) and encode fusion proteins with a C-terminus related to SMG1 phosphatidylinositol 3-kinase-related kinase. A readthrough locus is represented with GeneID:107282092. [provided by RefSeq, Feb 2016]

Canonical amino-acid sequenceUniProt

86 residues, UniProt reviewed canonical sequence.

>Q9H3K6|BOLA2
     1  MELSAEYLRE KLQRDLEAEH VEVEDTTLNR CSCSFRVLVV SAKFEGKPLL QRHRLVNACL
    61  AEELPHIHAF EQKTLTPDQW ARERQK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BOLA2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.34
Highest tissue expression: 58 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 58 nTPM
parathyroid gland: 57 nTPM
tongue: 56 nTPM
kidney: 39 nTPM
esophagus: 38 nTPM
testis: 37 nTPM

Single-cell type

oligodendrocytes: 12 nCPM
other brain neurons: 5.1 nCPM
brain excitatory neurons: 4.7 nCPM
brain inhibitory neurons: 4.5 nCPM
astrocytes: 4.3 nCPM
microglia: 4.3 nCPM

Immune cell

eosinophil: 20 nTPM
basophil: 19 nTPM
memory CD8 T-cell: 17 nTPM
memory B-cell: 17 nTPM
T-reg: 15 nTPM
NK-cell: 15 nTPM

Brain region

hypothalamus: 39 nTPM
cerebral cortex: 36 nTPM
midbrain: 35 nTPM
medulla oblongata: 34 nTPM
pons: 34 nTPM
white matter: 34 nTPM

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BOLA2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

GLRX3

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BOLA2 as an antibody target. Whether an autoantibody or antibody against BOLA2 could matter depends on whether native BOLA2 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BOLA2 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BOLA2 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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