Seroatlas · Human Serome Atlas

BOLA1

BolA-like protein 1

Also known as: BOLA1_HUMAN, CGI-143

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q9Y3E2
Gene: BOLA1
Ensembl: ENSG00000178096
Chromosome: 1
Canonical length: 137 aa
Protein class: Predicted intracellular proteins

OverviewNCBI Gene

Predicted to be involved in cell redox homeostasis; intracellular iron ion homeostasis; and iron-sulfur cluster assembly. Located in mitochondrion. Part of iron-sulfur cluster assembly complex. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

137 residues, UniProt reviewed canonical sequence.

>Q9Y3E2|BOLA1
     1  MLSGRLVLGL VSMAGRVCLC QGSAGSGAIG PVEAAIRTKL EEALSPEVLE LRNESGGHAV
    61  PPGSETHFRV AVVSSRFEGL SPLQRHRLVH AALAEELGGP VHALAIQART PAQWRENSQL
   121  DTSPPCLGGN KKTLGTP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BOLA1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.45
Highest tissue expression: 24 nTPM

Expression across tissuesHPA

Tissue

liver: 24 nTPM
kidney: 24 nTPM
colon: 22 nTPM
skeletal muscle: 21 nTPM
basal ganglia: 21 nTPM
skin: 21 nTPM

Single-cell type

epididymal principal cells: 65 nCPM
decidual stromal cells: 48 nCPM
esophageal basal cells: 47 nCPM
hepatocytes: 45 nCPM
enterocytes: 43 nCPM
prostatic club cells: 42 nCPM

Immune cell

plasmacytoid DC: 19 nTPM
naive CD4 T-cell: 19 nTPM
T-reg: 19 nTPM
naive CD8 T-cell: 18 nTPM
memory B-cell: 16 nTPM
MAIT T-cell: 15 nTPM

Brain region

white matter: 16 nTPM
cerebellum: 14 nTPM
thalamus: 14 nTPM
medulla oblongata: 13 nTPM
spinal cord: 13 nTPM
basal ganglia: 13 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.78
gnomAD pLI: 0.04
gnomAD missense Z: 0.51
DepMap mean gene effect: -0.12
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 9% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

BolA protein
BolA-like superfamily
BolA-like protein
BolA/IbaG family stress response and morphology regulators

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BOLA1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BOLA1 as an antibody target. Whether an autoantibody or antibody against BOLA1 could matter depends on whether native BOLA1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BOLA1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BOLA1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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