Seroatlas · Human Serome Atlas

BMERB1

bMERB domain-containing protein 1

Also known as: C16orf45, FLJ32618, MERB1_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q96MC5
Gene
BMERB1
Ensembl
ENSG00000166780
Chromosome
16
Canonical length
204 aa
Protein class
Predicted intracellular proteins
Subcellular location
Nucleoplasm,Cytosol

OverviewNCBI Gene

Predicted to be involved in negative regulation of microtubule depolymerization. Predicted to act upstream of or within negative regulation of cell motility involved in cerebral cortex radial glia guided migration. Predicted to be active in microtubule cytoskeleton. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

204 residues, UniProt reviewed canonical sequence.

>Q96MC5|BMERB1
     1  MELKQSLSTH LEAEKPLRRY GAVEETAWKT ERLGRNQLDI ISMAETTMMP EEIELEMAKI
    61  QRLREVLVRR ESELRFMMDD IQLCKDIMDL KQELQNLVAI PEKEKTKLQK QREDELIQKI
   121  HKLVQKRDFL VDDAEVERLR EQEEDKEMAD FLRIKLKPLD KVTKSPASSR AEKKAEPPPS
   181  KPTVAKTGLA LIKDCCGATQ CNIM

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BMERB1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.54
Highest tissue expression
190 nTPM

Expression across tissuesHPA

Tissue

  • cerebral cortex: 190 nTPM
  • hippocampal formation: 150 nTPM
  • amygdala: 144 nTPM
  • hypothalamus: 111 nTPM
  • cerebellum: 109 nTPM
  • basal ganglia: 97 nTPM

Single-cell type

  • late spermatids: 313 nCPM
  • oligodendrocyte progenitor cells: 156 nCPM
  • brain excitatory neurons: 130 nCPM
  • other brain neurons: 127 nCPM
  • distal convoluted tubule cells: 125 nCPM
  • brain inhibitory neurons: 116 nCPM

Immune cell

  • gdT-cell: 8.8 nTPM
  • memory CD8 T-cell: 5.2 nTPM
  • naive CD8 T-cell: 2.8 nTPM
  • T-reg: 2.6 nTPM
  • memory B-cell: 2.2 nTPM
  • memory CD4 T-cell: 2 nTPM

Brain region

  • pons: 183 nTPM
  • cerebral cortex: 159 nTPM
  • hippocampal formation: 150 nTPM
  • white matter: 123 nTPM
  • amygdala: 114 nTPM
  • medulla oblongata: 112 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.78
gnomAD pLI
0.14
DepMap mean gene effect
0
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

InteractionsUniProt · HPA

Protein binding partners of BMERB1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BMERB1 as an antibody target. Whether an autoantibody or antibody against BMERB1 could matter depends on whether native BMERB1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BMERB1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BMERB1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/BMERB1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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