Seroatlas · Human Serome Atlas

BEX3

Protein BEX3

Also known as: Bex, BEX3_HUMAN, DXS6984E, HGR74, NADE, NGFRAP1

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: Q00994
Gene: BEX3
Ensembl: ENSG00000166681
Chromosome: X
Canonical length: 111 aa
Protein class: Predicted intracellular proteins
Subcellular location: Cytosol

OverviewNCBI Gene

Enables identical protein binding activity. Predicted to be involved in negative regulation of protein ubiquitination and signal transduction. Predicted to act upstream of or within extrinsic apoptotic signaling pathway via death domain receptors. Located in cytosol. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

111 residues, UniProt reviewed canonical sequence.

>Q00994|BEX3
     1  MANIHQENEE MEQPMQNGEE DRPLGGGEGH QPAGNRRGQA RRLAPNFRWA IPNRQINDGM
    61  GGDGDDMEIF MEEMREIRRK LRELQLRNCL RILMGELSNH HDHHDEFCLM P

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BEX3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.65
Highest tissue expression: 830 nTPM

Expression across tissuesHPA

Tissue

choroid plexus: 830 nTPM
hypothalamus: 662 nTPM
cerebral cortex: 630 nTPM
basal ganglia: 624 nTPM
amygdala: 544 nTPM
hippocampal formation: 531 nTPM

Single-cell type

epididymal principal cells: 2,036 nCPM
cytotrophoblasts: 1,864 nCPM
migrating cytotrophoblasts: 1,467 nCPM
platelets: 1,458 nCPM
peritubular myoid cells: 973 nCPM
granulosa cells: 886 nCPM

Immune cell

naive CD4 T-cell: 151 nTPM
T-reg: 138 nTPM
memory CD4 T-cell: 72 nTPM
naive CD8 T-cell: 71 nTPM
total PBMC: 67 nTPM
NK-cell: 29 nTPM

Brain region

hypothalamus: 537 nTPM
choroid plexus: 476 nTPM
cerebral cortex: 357 nTPM
hippocampal formation: 344 nTPM
midbrain: 330 nTPM
basal ganglia: 326 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.96
gnomAD pLI: 0.62
DepMap mean gene effect: 0.08
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of BEX3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads BEX3 as an antibody target. Whether an autoantibody or antibody against BEX3 could matter depends on whether native BEX3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

BEX3 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label BEX3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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