BACE2

Protein identityUniProt · HPA

UniProt accession

Q9Y5Z0

Gene

BACE2

Ensembl

ENSG00000182240

Chromosome

21

Canonical length

518 aa

Protein class

Enzymes, Predicted intracellular proteins, Predicted membrane proteins, Transporters

Secretome location

Intracellular and membrane

OverviewNCBI Gene

This gene encodes an integral membrane glycoprotein that functions as an aspartic protease. The encoded protein cleaves amyloid precursor protein into amyloid beta peptide, which is a critical step in the etiology of Alzheimer's disease and Down syndrome. The protein precursor is further processed into an active mature peptide. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Canonical amino-acid sequenceUniProt

518 residues, UniProt reviewed canonical sequence.

>Q9Y5Z0|BACE2
     1  MGALARALLL PLLAQWLLRA APELAPAPFT LPLRVAAATN RVVAPTPGPG TPAERHADGL
    61  ALALEPALAS PAGAANFLAM VDNLQGDSGR GYYLEMLIGT PPQKLQILVD TGSSNFAVAG
   121  TPHSYIDTYF DTERSSTYRS KGFDVTVKYT QGSWTGFVGE DLVTIPKGFN TSFLVNIATI
   181  FESENFFLPG IKWNGILGLA YATLAKPSSS LETFFDSLVT QANIPNVFSM QMCGAGLPVA
   241  GSGTNGGSLV LGGIEPSLYK GDIWYTPIKE EWYYQIEILK LEIGGQSLNL DCREYNADKA
   301  IVDSGTTLLR LPQKVFDAVV EAVARASLIP EFSDGFWTGS QLACWTNSET PWSYFPKISI
   361  YLRDENSSRS FRITILPQLY IQPMMGAGLN YECYRFGISP STNALVIGAT VMEGFYVIFD
   421  RAQKRVGFAA SPCAEIAGAA VSEISGPFST EDVASNCVPA QSLSEPILWI VSYALMSVCG
   481  AILLVLIVLL LLPFRCQRRP RDPEVVNDES SLVRHRWK

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against BACE2 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

1

Mean surface accessibility (rSASA)

0.34

Highest tissue expression

22 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

0.69

gnomAD pLI

0.01

gnomAD missense Z

1.6

DepMap mean gene effect

0.1

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• amyloid-beta metabolic process
• glucose homeostasis
• melanosome organization
• membrane protein ectodomain proteolysis
• negative regulation of amyloid precursor protein biosynthetic process
• peptide hormone processing
• protein processing
• proteolysis

Molecular functions

• aspartic-type endopeptidase activity

Cellular components

• endoplasmic reticulum
• endosome
• Golgi apparatus
• melanosome membrane
• membrane
• plasma membrane
• trans-Golgi network

Protein domainsUniProt · Pfam · InterPro

• Aspartic peptidase A1
• Aspartic peptidase, active site
• Beta-secretase BACE
• Aspartic peptidase domain superfamily
• Peptidase family A1 domain
• Memapsin-like
• Eukaryotic aspartyl protease
• Beta-secretase BACE2

KeywordsUniProt

• Aspartyl protease
• Autocatalytic cleavage
• Cell membrane
• Disulfide bond
• Endoplasmic reticulum
• Endosome
• Glycoprotein
• Golgi apparatus
• Hydrolase
• Membrane
• Protease
• Signal
• Transmembrane
• Transmembrane helix
• Zymogen

InteractionsUniProt · HPA

Protein binding partners of BACE2 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

• RTN3
• RTN4