Seroatlas · Human Serome Atlas

AUNIP

Aurora kinase A- and ninein-interacting protein

Also known as: AIBp, AUNIP_HUMAN, C1orf135, MGC2603

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9H7T9
Gene
AUNIP
Ensembl
ENSG00000127423
Chromosome
1
Canonical length
357 aa
Protein class
Predicted intracellular proteins
Subcellular location
Centrosome

OverviewNCBI Gene

Enables damaged DNA binding activity. Involved in double-strand break repair via homologous recombination; negative regulation of double-strand break repair via nonhomologous end joining; and spindle organization. Located in centrosome; site of DNA damage; and spindle pole. [provided by Alliance of Genome Resources, Jul 2025]

Canonical amino-acid sequenceUniProt

357 residues, UniProt reviewed canonical sequence.

>Q9H7T9|AUNIP
     1  MRRTGPEEEA CGVWLDAAAL KRRKVQTHLI KPGTKMLTLL PGERKANIYF TQRRAPSTGI
    61  HQRSIASFFT LQPGKTNGSD QKSVSSHTES QINKESKKNA TQLDHLIPGL AHDCMASPLA
   121  TSTTADIQEA GLSPQSLQTS GHHRMKTPFS TELSLLQPDT PDCAGDSHTP LAFSFTEDLE
   181  SSCLLDRKEE KGDSARKWEW LHESKKNYQS MEKHTKLPGD KCCQPLGKTK LERKVSAKEN
   241  RQAPVLLQTY RESWNGENIE SVKQSRSPVS VFSWDNEKND KDSWSQLFTE DSQGQRVIAH
   301  NTRAPFQDVT NNWNWDLGPF PNSPWAQCQE DGPTQNLKPD LLFTQDSEGN QVIRHQF

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against AUNIP can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Intracellular
Secreted
No
Transmembrane segments
0
Mean surface accessibility (rSASA)
0.7
Highest tissue expression
15 nTPM

Expression across tissuesHPA

Tissue

  • testis: 15 nTPM
  • bone marrow: 5.9 nTPM
  • placenta: 1.6 nTPM
  • tonsil: 1.6 nTPM
  • esophagus: 1.3 nTPM
  • cerebral cortex: 1.2 nTPM

Single-cell type

  • late spermatids: 186 nCPM
  • early primary spermatocytes: 81 nCPM
  • oocytes: 78 nCPM
  • cardiomyocytes: 75 nCPM
  • early spermatids: 67 nCPM
  • epicardial cells: 48 nCPM

Immune cell

  • basophil: 1.5 nTPM
  • intermediate monocyte: 1 nTPM
  • T-reg: 0.8 nTPM
  • classical monocyte: 0.7 nTPM
  • myeloid DC: 0.6 nTPM
  • non-classical monocyte: 0.6 nTPM

Brain region

  • cerebellum: 4 nTPM
  • cerebral cortex: 4 nTPM
  • amygdala: 3.3 nTPM
  • white matter: 3.3 nTPM
  • pons: 3.1 nTPM
  • basal ganglia: 2.9 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
1.58
gnomAD pLI
0
gnomAD missense Z
0.3
DepMap mean gene effect
-0.02
DepMap dependency class
selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

  • Aurora kinase A- and ninein interacting protein
  • Aurora kinase A and ninein interacting protein

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of AUNIP in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads AUNIP as an antibody target. Whether an autoantibody or antibody against AUNIP could matter depends on whether native AUNIP is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

AUNIP is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label AUNIP as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/AUNIP. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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