Seroatlas · Human Serome Atlas

ATP1B3

Sodium/potassium-transporting ATPase subunit beta-3

Also known as: AT1B3_HUMAN, CD298, FLJ29027

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: P54709
Gene: ATP1B3
Ensembl: ENSG00000069849
Chromosome: 3
Canonical length: 279 aa
Protein class: CD markers, Metabolic proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters
Subcellular location: Plasma membrane

OverviewNCBI Gene

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 3 subunit. This gene encodes a beta 3 subunit. A pseudogene exists for this gene, and it is located on chromosome 2. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

279 residues, UniProt reviewed canonical sequence.

>P54709|ATP1B3
     1  MTKNEKKSLN QSLAEWKLFI YNPTTGEFLG RTAKSWGLIL LFYLVFYGFL AALFSFTMWV
    61  MLQTLNDEVP KYRDQIPSPG LMVFPKPVTA LEYTFSRSDP TSYAGYIEDL KKFLKPYTLE
   121  EQKNLTVCPD GALFEQKGPV YVACQFPISL LQACSGMNDP DFGYSQGNPC ILVKMNRIIG
   181  LKPEGVPRID CVSKNEDIPN VAVYPHNGMI DLKYFPYYGK KLHVGYLQPL VAVQVSFAPN
   241  NTGKEVTVEC KIDGSANLKS QDDRDKFLGR VMFKITARA

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP1B3 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Cell surface
Secreted: No
Transmembrane segments: 1
Mean surface accessibility (rSASA): 0.33
Highest tissue expression: 384 nTPM

Expression across tissuesHPA

Tissue

adrenal gland: 384 nTPM
choroid plexus: 367 nTPM
skin: 245 nTPM
adipose tissue: 217 nTPM
lung: 184 nTPM
esophagus: 176 nTPM

Single-cell type

somatotrophs: 3,948 nCPM
monocytes: 1,867 nCPM
late spermatids: 1,625 nCPM
lactotrophs: 1,313 nCPM
vascular smooth muscle cells: 1,252 nCPM
cdc: 1,109 nCPM

Immune cell

non-classical monocyte: 262 nTPM
intermediate monocyte: 175 nTPM
classical monocyte: 104 nTPM
total PBMC: 104 nTPM
myeloid DC: 104 nTPM
memory CD8 T-cell: 75 nTPM

Brain region

choroid plexus: 139 nTPM
cerebellum: 90 nTPM
pons: 89 nTPM
hypothalamus: 84 nTPM
cerebral cortex: 80 nTPM
medulla oblongata: 78 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 0.68
gnomAD pLI: 0.1
gnomAD missense Z: 1.94
DepMap mean gene effect: -0.32
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 8% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ATP1B3 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ATP1B3 as an antibody target. Whether an autoantibody or antibody against ATP1B3 could matter depends on whether native ATP1B3 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ATP1B3 is annotated at the cell surface, where native ATP1B3 is exposed to circulating antibodies and is a prime autoantibody target that could block, deplete, or overstimulate it.

Annotation status

The present source text does not explicitly label ATP1B3 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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