ATP13A5

Protein identityUniProt · HPA

UniProt accession

Q4VNC0

Gene

ATP13A5

Ensembl

ENSG00000187527

Chromosome

3

Canonical length

1218 aa

Protein class

Predicted membrane proteins

Subcellular location

Nucleoplasm,Plasma membrane

OverviewNCBI Gene

This gene encodes a member of the P5 subfamily of P-type transport ATPases. P-type ATPases form a large superfamily of cation and lipid pumps that transport inorganic cations and other substrates across cell membranes. P5 ATPases are localized to membranes of the endoplasmic reticulum (ER) and serve many important functions including transport of cargo proteins to the Golgi, glycosylation and cell wall biosynthesis, control of protein insertion orientation, 3-hydroxy-3-methylglutaryl-CoA reductase (HMGR) degradation, and sensitivity to unfolded protein response (UPR) activators. The encoded protein is organized into three cytoplasmic domains (A, P, and N) and two membrane-embedded domains (T and S). The N-domain binds ATP and serves as a built-in protein kinase, which phosphorylates the P-domain. The A-domain is an intrinsic protein phosphatase, which dephosphorylates the P-domain once during each catalytic cycle. [provided by RefSeq, Jul 2017]

Canonical amino-acid sequenceUniProt

1218 residues, UniProt reviewed canonical sequence.

>Q4VNC0|ATP13A5
     1  MEENSKKDHR ALLNQGEEDE LEVFGYRDHN VRKAFCLVAS VLTCGGLLLV FYWRPQWRVW
    61  ANCIPCPLQE ADTVLLRTTD EFQRYMRKKV FCLYLSTLKF PVSKKWEESL VADRHSVINQ
   121  ALIKPELKLR CMEVQKIRYV WNDLEKRFQK VGLLEDSNSC SDIHQTFGLG LTSEEQEVRR
   181  LVCGPNAIEV EIQPIWKLLV KQVLNPFYVF QAFTLTLWLS QGYIEYSVAI IILTVISIVL
   241  SVYDLRQQSV KLHNLVEDHN KVQVTIIVKD KGLEELESRL LVPGDILILP GKFSLPCDAV
   301  LIDGSCVVNE GMLTGESIPV TKTPLPQMEN TMPWKCHSLE DYRKHVLFCG TEVIQVKPSG
   361  QGPVRAVVLQ TGYNTAKGDL VRSILYPRPL NFKLYSDAFK FIVFLACLGV MGFFYALGVY
   421  MYHGVPPKDT VTMALILLTV TVPPVLPAAL TIGNVYAQKR LKKKKIFCIS PQRINMCGQI
   481  NLVCFDKTGT LTEDGLDLWG TVPTADNCFQ EAHSFASGQA VPWSPLCAAM ASCHSLILLN
   541  GTIQGDPLDL KMFEGTAWKM EDCIVDSCKF GTSVSNIIKP GPKASKSPVE AIITLCQFPF
   601  SSSLQRMSVI AQLAGENHFH VYMKGAPEMV ARFCRSETVP KNFPQELRSY TVQGFRVIAL
   661  AHKTLKMGNL SEVEHLAREK VESELTFLGL LIMENRLKKE TKLVLKELSE ARIRTVMITG
   721  DNLQTAITVA KNSEMIPPGS QVIIVEADEP EEFVPASVTW QLVENQETGP GKKEIYMHTG
   781  NSSTPRGEGG SCYHFAMSGK SYQVIFQHFN SLLPKILVNG TVFARMSPGQ KSSLIEEFQK
   841  LNYYVGMCGD GANDCGALKA AHAGISLSEQ EASVASPFTS KTTNIQCVPH LIREGRAALV
   901  SSFGVFKYLT MYGIIQFISA LLLYWQLQLF GNYQYLMQDV AITLMVCLTM SSTHAYPKLA
   961  PYRPAGQLLS PPLLLSIFLN SCFSCIVQIS AFLYVKQQPW YCEVYQYSEC FLANQSNFST
  1021  NVSLERNWTG NATLIPGSIL SFETTTLWPI TTINYITVAF IFSKGKPFRK PIYTNYIFSF
  1081  LLLAALGLTI FILFSDFQVI YRGMELIPTI TSWRVLILVV ALTQFCVAFF VEDSILQNHE
  1141  LWLLIKREFG FYSKSQYRTW QKKLAEDSTW PPINRTDYSG DGKNGFYING GYESHEQIPK
  1201  RKLKLGGQPT EQHFWARL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ATP13A5 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability

Cell surface

Secreted

No

Transmembrane segments

10

Mean surface accessibility (rSASA)

0.27

Highest tissue expression

33 nTPM

Expression across tissuesHPA

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)

1.29

gnomAD pLI

0

gnomAD missense Z

0.61

DepMap mean gene effect

0.09

DepMap dependency class

none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

• intracellular calcium ion homeostasis
• monoatomic ion transmembrane transport
• polyamine transmembrane transport

Molecular functions

• ATP binding
• ATP hydrolysis activity
• ATPase-coupled monoatomic cation transmembrane transporter activity
• metal ion binding
• P-type ion transporter activity
• polyamine transmembrane transporter activity

Cellular components

• late endosome membrane
• plasma membrane

Protein domainsUniProt · Pfam · InterPro

• P-type ATPase
• Cation-transporting P-type ATPase, N-terminal
• P-type ATPase, subfamily V
• P-type ATPase, A domain superfamily
• P-type ATPase, phosphorylation site
• HAD superfamily
• P-type ATPase, transmembrane domain superfamily
• P-type ATPase, cytoplasmic domain N
• HAD-like superfamily
• P-type ATPase, haloacid dehalogenase domain
• P5B-type ATPase, N-terminal
• P5B-type ATPase
• P-type ATPase, A domain
• P-type ATPase actuator domain
• Cation transporter/ATPase, N-terminus
• P5-type ATPase cation transporter
• P-type ATPase, cytoplasmic domain N

KeywordsUniProt

• ATP-binding
• Glycoprotein
• Magnesium
• Membrane
• Metal-binding
• Nucleotide-binding
• Translocase
• Transmembrane
• Transmembrane helix