Seroatlas · Human Serome Atlas

ARMCX1

Armadillo repeat-containing X-linked protein 1

Also known as: ALEX1, ARMX1_HUMAN, GASP7

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession
Q9P291
Gene
ARMCX1
Ensembl
ENSG00000126947
Chromosome
X
Canonical length
453 aa
Protein class
Predicted membrane proteins
Subcellular location
Nucleoplasm,Mitochondria,Cytosol

OverviewNCBI Gene

This gene encodes a member of the ALEX family of proteins and may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and two Armadillo (arm) repeats. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members, including ALEX2 and ALEX3, on the X chromosome. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

453 residues, UniProt reviewed canonical sequence.

>Q9P291|ARMCX1
     1  MGRTREAGCV AAGVVIGAGA CYCVYRLAWG RDENEKIWDE DEESTDTSEI GVETVKGAKT
    61  NAGAGSGAKL QGDSEVKPEV SLGLEDCPGV KEKAHSGSHS GGGLEAKAKA LFNTLKEQAS
   121  AKAGKGARVG TISGNRTLAP SLPCPGGRGG GCHPTRSGSR AGGRASGKSK GKARSKSTRA
   181  PATTWPVRRG KFNFPYKIDD ILSAPDLQKV LNILERTNDP FIQEVALVTL GNNAAYSFNQ
   241  NAIRELGGVP IIAKLIKTKD PIIREKTYNA LNNLSVNAEN QGKIKTYISQ VCDDTMVCRL
   301  DSAVQMAGLR LLTNMTVTNH YQHLLSYSFP DFFALLFLGN HFTKIQIMKL IINFTENPAM
   361  TRELVSCKVP SELISLFNKE WDREILLNIL TLFENINDNI KNEGLASSRK EFSRSSLFFL
   421  FKESGVCVKK IKALANHNDL VVKVKVLKVL TKL

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARMCX1 can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability
Other membrane
Secreted
No
Transmembrane segments
1
Mean surface accessibility (rSASA)
0.43
Highest tissue expression
47 nTPM

Expression across tissuesHPA

Tissue

  • ovary: 47 nTPM
  • adrenal gland: 32 nTPM
  • blood vessel: 32 nTPM
  • heart muscle: 31 nTPM
  • colon: 30 nTPM
  • endometrium: 29 nTPM

Single-cell type

  • smooth muscle cells: 78 nCPM
  • decidual stromal cells: 69 nCPM
  • ovarian stromal cells: 68 nCPM
  • melanocytes: 60 nCPM
  • schwann cells: 53 nCPM
  • fibroblasts: 47 nCPM

Immune cell

  • myeloid DC: 7.7 nTPM
  • plasmacytoid DC: 4 nTPM
  • classical monocyte: 3.3 nTPM
  • intermediate monocyte: 3.1 nTPM
  • naive CD8 T-cell: 2.7 nTPM
  • NK-cell: 1.8 nTPM

Brain region

  • hypothalamus: 27 nTPM
  • pons: 26 nTPM
  • choroid plexus: 25 nTPM
  • basal ganglia: 24 nTPM
  • midbrain: 24 nTPM
  • cerebral cortex: 24 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance)
0.96
gnomAD pLI
0.07
gnomAD missense Z
1.83
DepMap mean gene effect
0.06
DepMap dependency class
none

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 5% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARMCX1 in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARMCX1 as an antibody target. Whether an autoantibody or antibody against ARMCX1 could matter depends on whether native ARMCX1 is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARMCX1 is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARMCX1 as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

Canonical record: https://seroatlas.com/gene/ARMCX1. Study-independent annotations aggregated from UniProt, Human Protein Atlas, PubMed, IEDB, Pfam, InterPro, Gene Ontology, AlphaFold, gnomAD, DepMap, ClinVar, TCGA. Catalog release seroatlas-reviewed-human-uniprot-20260313.

Seroatlas is the reference for exploring autoantibody and antibody serology at the human-protein level: the autoreactome and human serome, multiplex serology (HuProt, HuScan, VirScan, PhIP-Seq).

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