Seroatlas · Human Serome Atlas

ARID3C

AT-rich interactive domain-containing protein 3C

Also known as: ARI3C_HUMAN

Cross-references: UniProt · Ensembl · Human Protein Atlas · GeneCards · NCBI Gene

Protein identityUniProt · HPA

UniProt accession: A6NKF2
Gene: ARID3C
Ensembl: ENSG00000205143
Chromosome: 9
Canonical length: 412 aa
Protein class: Predicted intracellular proteins, Transcription factors

OverviewNCBI Gene

This gene is a member of the ARID (AT-rich interaction domain) family of proteins. The ARID domain is a helix-turn-helix motif-based DNA-binding domain. ARID family members have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification. [provided by RefSeq, Jul 2008]

Canonical amino-acid sequenceUniProt

412 residues, UniProt reviewed canonical sequence.

>A6NKF2|ARID3C
     1  MEALQKQQAA RLAQGVGPLA PACPLLPPQP PLPDHRTLQA PEGALGNVGA EEEEDAEEDE
    61  EKREEAGAEE EAAEESRPGA QGPSSPSSQP PGLHPHEWTY EEQFKQLYEL DADPKRKEFL
   121  DDLFSFMQKR GTPVNRVPIM AKQVLDLYAL FRLVTAKGGL VEVINRKVWR EVTRGLSLPT
   181  TITSAAFTLR TQYMKYLYPY ECETRALSSP GELQAAIDSN RREGRRQAYT ATPLFGLAGP
   241  PPRGAQDPAL GPGPAPPATQ SSPGPAQGST SGLPAHACAQ LSPSPIKKEE SGIPNPCLAL
   301  PVGLALGPTR EKLAPEEPPE KRAVLMGPMD PPRPCMPPSF LPRGKVPLRE ERLDGPLNLA
   361  GSGISSINMA LEINGVVYTG VLFARRQPVP ASQGPTNPAP PPSTGPPSSI LP

LocalizationUniProt · AlphaFold · HPA

Whether an antibody against ARID3C can act on the native protein depends on physical access: surface and secreted proteins are reachable by circulating antibodies, intracellular proteins usually are not.

Antibody reachability: Intracellular
Secreted: No
Transmembrane segments: 0
Mean surface accessibility (rSASA): 0.59
Highest tissue expression: 10 nTPM

Expression across tissuesHPA

Tissue

liver: 10 nTPM
cerebral cortex: 0.3 nTPM
skin: 0.3 nTPM
testis: 0.3 nTPM
cerebellum: 0.2 nTPM
fallopian tube: 0.2 nTPM

Single-cell type

hepatocytes: 4.3 nCPM
gastric progenitor cells: 1.3 nCPM
late spermatids: 0.8 nCPM
retinal amacrine cells: 0.7 nCPM
basal prostatic cells: 0.6 nCPM
early spermatids: 0.5 nCPM

Immune cell

basophil: 0 nTPM
classical monocyte: 0 nTPM
eosinophil: 0 nTPM
gdT-cell: 0 nTPM
intermediate monocyte: 0 nTPM
MAIT T-cell: 0 nTPM

Brain region

pons: 3.4 nTPM
cerebral cortex: 2.6 nTPM
hypothalamus: 2.4 nTPM
medulla oblongata: 2.3 nTPM
white matter: 1.7 nTPM
cerebellum: 1.5 nTPM

Genetic constraint and essentialitygnomAD · DepMap

Does the body need this protein intact? Low LOEUF or a strong DepMap dependency means loss or blockade of the protein is likely to be felt.

gnomAD LOEUF (loss-of-function intolerance): 1.4
gnomAD pLI: 0
gnomAD missense Z: 0.49
DepMap mean gene effect: -0.04
DepMap dependency class: selective

Cancer expressionTCGA

Across TCGA tumor cohorts, this protein is over-expressed in roughly 4% of surveyed tumor types (aggregate summary; per-cohort expression, alteration, and survival load in the interactive view).

OntologyGO

Biological processes

Molecular functions

Cellular components

Protein domainsUniProt · Pfam · InterPro

KeywordsUniProt

InteractionsUniProt · HPA

Protein binding partners of ARID3C in the human serome: UniProt-annotated complex subunits plus reported interactors. Each links to its own Seroatlas record.

NPM1

Antibody and autoantibody relevanceSeroatlas analysis

Seroatlas reads ARID3C as an antibody target. Whether an autoantibody or antibody against ARID3C could matter depends on whether native ARID3C is physically reachable, whether the body needs it intact, and whether it acts in a disease-relevant tissue.

ARID3C is annotated as predominantly intracellular. Intracellular proteins are common autoantibody markers, becoming visible to the immune system after cell injury or altered processing, but are usually markers of disease rather than direct drivers.

Annotation status

The present source text does not explicitly label ARID3C as an autoantigen. Seroatlas presents hypothesis context only and does not manufacture a known-serology claim.

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